Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge in the health impact of spaceflights, we simulate microgravity with a 5-day dry immersion in 18 healthy women (ClinicalTrials.gov Identifier: NCT05043974). Here we show that dry immersion rapidly induces a sedentarily-like metabolism shift mimicking the beginning of a metabolic syndrome with a drop in glucose tolerance, an increase in the atherogenic index of plasma, and an impaired lipid profile. Bone remodeling markers suggest a decreased bone formation coupled with an increased bone resorption. Fluid shifts and muscular unloading participate to a marked cardiovascular and sensorimotor deconditioning with decreased orthostatic tolerance, aerobic capacity, and postural balance. Collected datasets provide a comprehensive multi-systemic assessment of dry immersion effects in women and pave the way for future sex-based evaluations of countermeasures.

处于微重力状态的宇航员会经历多系统失调，影响他们的飞行效率，并在返回地球重力时引发功能障碍。为了填补航天飞行对健康影响方面的性别知识空白，我们对 18 名健康女性进行为期 5 天的干浸，以模拟微重力（ClinicalTrials.gov 标识符：NCT05043974）。在这里，我们表明，干浸泡会迅速诱导类似静坐的代谢转变，模仿代谢综合征的开始，伴有葡萄糖耐量下降、血浆动脉粥样硬化指数增加和脂质谱受损。骨重塑标志物表明骨形成减少且骨吸收增加。液体转移和肌肉减负荷会导致明显的心血管和感觉运动失调，导致直立耐受力、有氧能力和姿势平衡下降。收集的数据集提供了对女性干浸效应的全面多系统评估，并为未来基于性别的对策评估铺平了道路。