<br>一种与戊二醛交联的多功能生物贴片，可增强机械性能、抗凝性能和抗钙化性能,Journal of Materials Chemistry B

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一种与戊二醛交联的多功能生物贴片，可增强机械性能、抗凝性能和抗钙化性能
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2023-10-12 , DOI: 10.1039/d3tb01724a
Jiahao Chang ₁ , Liyin Yu ₂ , Jiao Lei ₁ , Xiaoli Liu ₁ , Chunxiao Li ₃ , Yali Zheng ₃ , Hong Chen _{1,

3}

Affiliation

用于治疗瓣膜疾病的生物贴片已在临床试验中得到评估。研究表明，这些装置在植入后几年内发生故障可能是由于细胞毒性、免疫反应、钙化和血栓形成。其中一些影响可能是由于材料制备中使用的戊二醛交联过程造成的。许多研究侧重于控制钙化的策略，而另一些研究则侧重于预防微血栓形成。在目前的工作中，我们引入了氨基封端的聚乙二醇（NH ₂ –PEG-NH ₂ ）作为分子间桥，不仅消除了游离醛基以防止钙化，而且还引入了抗凝剂的附着位点分子。此外，PEG本身是一种亲水性聚合物，具有良好的生物相容性，可以有效防止血液接触早期蛋白质吸附导致血栓形成。进一步共价连接肝素后，修饰的牛心包（BP）表现出很强的抗钙化（钙含量：39.3 ± 3.1 μg mg ^-1 ）和抗凝血特性（部分凝血活酶时间：>300 s）。对临床使用很重要的生物相容性和机械性能也通过修饰得到了改善。这项工作中使用的策略包括改进临床使用的瓣膜产品的新想法和技术。

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A multifunctional bio-patch crosslinked with glutaraldehyde for enhanced mechanical performance, anti-coagulation properties, and anti-calcification properties

Bio-patches for the treatment of valvular disease have been evaluated in clinical trials. It has been shown that failure of these devices, occurring within a few years of implantation, may be due to cytotoxicity, immune response, calcification and thrombosis. Some of these effects may be due to the glutaraldehyde crosslinking process used in the preparation of the materials. A number of studies have focused on strategies to control calcification, while others have concentrated on the prevention of micro-thrombus formation. In the present work, we have introduced amino-terminated poly(ethylene glycol) (NH₂–PEG–NH₂) as an intermolecular bridge, which not only eliminates free aldehyde groups to prevent calcification, but also introduces sites for the attachment of anticoagulant molecules. Furthermore, PEG, itself a hydrophilic polymer with good biocompatibility, may effectively prevent protein adsorption in the early stages of blood contact leading to thrombus formation. After further covalent attachment of heparin, modified bovine pericardium (BP) showed strong anti-calcification (calcium content: 39.3 ± 3.1 μg mg⁻¹) and anti-coagulation properties (partial thromboplastin time: >300 s). The biocompatibility and mechanical properties, important for clinical use, were also improved by modification. The strategy used in this work includes new ideas and technologies for the improvement of valve products used in the clinic.

更新日期：2023-10-12

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