Palladium-Catalyzed Aminoalkylative Cyclization Enables Modular Synthesis of Exocyclic 1,3-Dienes,Angewandte Chemie International Edition

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Palladium-Catalyzed Aminoalkylative Cyclization Enables Modular Synthesis of Exocyclic 1,3-Dienes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2023-10-10 , DOI: 10.1002/anie.202311603
Suchen Zou ₁ , Zeyu Zhao ₁ , Hanmin Huang _{1,

2}

Affiliation

An unprecedented three-component reaction building on palladium-catalyzed aminoalkylative cyclization between an aminoenyne, an aldehyde and a boronic acid or diphenylsilane is developed. This provides a facile access to multisubstituted exocyclic 1,3-dienes bearing 5 to 8-membered saturated N-heterocycles in a regioselective and stereodivergent fashion.

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