Background

There is no randomized study comparing the isocaloric (ICHD) and hypocaloric diet (HCD) in PCOS subjects.

Objective

To compare ICHD and HCD in weight-matched PCOS subjects.

Methods

PCOS subjects were randomized to receive either a HCD or ICHD. Clinical, biochemical, hormonal and dietary assessments were performed at baseline, 3 months and at one year.

Results

There were 168 PCOS subjects randomized to receive either ICHD (n = 84) or HCD (n = 84). We observed that while the hypocaloric diet was more effective in reducing weight, both the diets were effective in improving clinical symptoms. Around 50% patients showed improvement in clinical symptoms at 3 months and 30% were on diet alone therapy at one year in both the groups. The effect on hirsuitism was modest by both the diets at one year. The effectiveness of both the diets was similar with both the per protocol and the Intention to treat analysis; nevertheless, there was a greater loss to follow-up in patients on ICHD with high baseline caloric intakes.

Conclusion

HCD and ICHD are equally effective in as many as 30% patients with mild symptoms over long term. Patients having higher caloric intakes at baseline should not be offered isocaloric diets.

中文翻译：

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等热量饮食在改善 PCOS 患者症状方面与低热量饮食一样有效

背景

目前还没有比较多囊卵巢综合征受试者等热量饮食 (ICHD) 和低热量饮食 (HCD) 的随机研究。

客观的

比较体重匹配的 PCOS 受试者的 ICHD 和 HCD。

方法

PCOS 受试者被随机分配接受 HCD 或 ICHD。在基线、3个月和一年时进行临床、生化、激素和饮食评估。

结果

有 168 名 PCOS 受试者随机接受 ICHD ( n = 84) 或 HCD ( n = 84)。我们观察到，虽然低热量饮食在减肥方面更有效，但这两种饮食都能有效改善临床症状。两组中约有 50% 的患者在 3 个月时临床症状有所改善，30% 的患者在一年时仅接受饮食治疗。一年后，两种饮食对多毛症的影响都很有限。根据方案和意向治疗分析，两种饮食的有效性相似；然而，基线热量摄入较高的 ICHD 患者的随访损失更大。

结论

HCD 和 ICHD 对于多达 30% 的长期轻度症状患者同样有效。基线时热量摄入较高的患者不应接受等热量饮食。