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Cytotoxic Epipolythiodioxopiperazines from the Deep-Sea-Derived Fungus Exophiala mesophila MCCC 3A00939
Journal of Natural Products ( IF 3.3 ) Pub Date : 2023-10-09 , DOI: 10.1021/acs.jnatprod.3c00534 Meimei Cheng 1 , Xuli Tang 2 , Zongze Shao 3 , Guoqiang Li 4, 5 , Qingqiang Yao 1
Journal of Natural Products ( IF 3.3 ) Pub Date : 2023-10-09 , DOI: 10.1021/acs.jnatprod.3c00534 Meimei Cheng 1 , Xuli Tang 2 , Zongze Shao 3 , Guoqiang Li 4, 5 , Qingqiang Yao 1
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Four new aranotin-type epipolythiodioxopiperazines, graphiumins K–N (1–4), along with four known analogues (5–8), were isolated from the deep-sea-derived fungus Exophiala mesophila MCCC 3A00939. Their structures were elucidated by detailed interpretation of NMR and mass spectrometric data. The absolute configuration of the isolates was deduced by a single-crystal X-ray diffraction analysis and the comparisons of experimental electronic circular dichroism (ECD) data with calculated ECD spectra. Graphiumins K (1) and L (2) exhibited cytotoxic activities against the K562, H69AR, and MDA-MB-231 cancer cells with IC50 values ranging from 2.3 to 5.9 μM.
中文翻译：
来自深海衍生真菌 Exophiala mesophila MCCC 的细胞毒性表聚硫二氧代哌嗪 3A00939
从深海真菌Exophiala mesophila MCCC 3A00939中分离出四种新的阿南丁型表聚硫二氧代哌嗪、graphiumins K–N ( 1 – 4 ) 以及四种已知的类似物 ( 5 – 8 )。通过对核磁共振和质谱数据的详细解释，阐明了它们的结构。通过单晶 X 射线衍射分析以及实验电子圆二色性 (ECD) 数据与计算的 ECD 光谱的比较，推导出分离物的绝对构型。Graphiumins K ( 1 ) 和 L ( 2 ) 对 K562、H69AR 和 MDA-MB-231 癌细胞表现出细胞毒活性，IC 50值范围为 2.3 至 5.9 μM。
更新日期：2023-10-09
中文翻译：
来自深海衍生真菌 Exophiala mesophila MCCC 的细胞毒性表聚硫二氧代哌嗪 3A00939
从深海真菌Exophiala mesophila MCCC 3A00939中分离出四种新的阿南丁型表聚硫二氧代哌嗪、graphiumins K–N ( 1 – 4 ) 以及四种已知的类似物 ( 5 – 8 )。通过对核磁共振和质谱数据的详细解释，阐明了它们的结构。通过单晶 X 射线衍射分析以及实验电子圆二色性 (ECD) 数据与计算的 ECD 光谱的比较，推导出分离物的绝对构型。Graphiumins K ( 1 ) 和 L ( 2 ) 对 K562、H69AR 和 MDA-MB-231 癌细胞表现出细胞毒活性，IC 50值范围为 2.3 至 5.9 μM。
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