Microsystems & Nanoengineering ( IF 7.3 ) Pub Date : 2023-10-10 , DOI: 10.1038/s41378-023-00597-x
Bowen Ji 1, 2, 3 , Fanqi Sun 1, 2, 3 , Jiecheng Guo 4 , Yuhao Zhou 1, 2, 3 , Xiaoli You 1, 2, 3 , Ye Fan 5 , Longchun Wang 6 , Mengfei Xu 6 , Wen Zeng 2 , Jingquan Liu 6 , Minghao Wang 5 , Huijing Hu 4 , Honglong Chang 2
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Bacterial cellulose (BC), a natural biomaterial synthesized by bacteria, has a unique structure of a cellulose nanofiber-weaved three-dimensional reticulated network. BC films can be ultrasoft with sufficient mechanical strength, strong water absorption and moisture retention and have been widely used in facial masks. These films have the potential to be applied to implantable neural interfaces due to their conformality and moisture, which are two critical issues for traditional polymer or silicone electrodes. In this work, we propose a micro-electrocorticography (micro-ECoG) electrode named “Brainmask”, which comprises a BC film as the substrate and separated multichannel parylene-C microelectrodes bonded on the top surface. Brainmask can not only guarantee the precise position of microelectrode sites attached to any nonplanar epidural surface but also improve the long-lasting signal quality during acute implantation with an exposed cranial window for at least one hour, as well as the in vivo recording validated for one week. This novel ultrasoft and moist device stands as a next-generation neural interface regardless of complex surface or time of duration.
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
Brainmask:超柔软、湿润的微皮质电图电极,可实现精确定位和持久记录
细菌纤维素(BC)是一种由细菌合成的天然生物材料,具有纤维素纳米纤维编织的三维网状网络的独特结构。BC薄膜具有超柔软性、足够的机械强度、较强的吸水性和保湿性,已广泛应用于面膜领域。这些薄膜具有应用于植入式神经接口的潜力,因为它们的保形性和湿度是传统聚合物或硅胶电极的两个关键问题。在这项工作中,我们提出了一种名为“Brainmask”的微皮质电图(micro-ECoG)电极,它包括作为基底的BC薄膜和粘合在顶表面上的分离的多通道聚对二甲苯-C微电极。Brainmask不仅可以保证附着在任何非平面硬膜外表面的微电极位点的精确位置,还可以提高急性植入过程中暴露颅窗至少一小时的持久信号质量,以及经过一小时验证的体内记录星期。无论复杂的表面或持续时间如何,这种新颖的超柔软和潮湿的设备都是下一代神经接口。