Nature Communications ( IF 14.7 ) Pub Date : 2023-10-09 , DOI: 10.1038/s41467-023-42041-8
Kristie Huda 1 , Dylan J Lawrence 1, 2 , Weylan Thompson 2 , Sarah H Lindsey 3 , Carolyn L Bayer 1
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Altered vasoactivity is a major characteristic of cardiovascular and oncological diseases, and many therapies are therefore targeted to the vasculature. Therapeutics which are selective for the diseased vasculature are ideal, but whole-body selectivity of a therapeutic is challenging to assess in practice. Vessel myography is used to determine the functional mechanisms and evaluate pharmacological responses of vascularly-targeted therapeutics. However, myography can only be performed on ex vivo sections of individual arteries. We have developed methods for implementation of spherical-view photoacoustic tomography for non-invasive and in vivo myography. Using photoacoustic tomography, we demonstrate the measurement of acute vascular reactivity in the systemic vasculature and the placenta of female pregnant mice in response to two vasodilators. Photoacoustic tomography simultaneously captures the significant acute vasodilation of major arteries and detects selective vasoactivity of the maternal-fetal vasculature. Photoacoustic tomography has the potential to provide invaluable preclinical information on vascular response that cannot be obtained by other established methods.
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雌性妊娠小鼠急性全身血管活动的体内无创全身肌电图
血管活性改变是心血管和肿瘤疾病的主要特征,因此许多疗法都是针对脉管系统的。对患病脉管系统具有选择性的治疗是理想的,但在实践中评估治疗的全身选择性具有挑战性。血管肌动描记用于确定血管靶向治疗的功能机制并评估药理反应。然而,肌动描记术只能在单个动脉的离体切片上进行。我们开发了用于非侵入性和体内肌动描记术的球面视图光声断层扫描的实施方法。使用光声断层扫描,我们展示了雌性怀孕小鼠的全身脉管系统和胎盘对两种血管扩张剂的反应的急性血管反应性的测量。光声断层扫描同时捕获主要动脉的显着急性血管舒张并检测母胎脉管系统的选择性血管活动。光声断层扫描有潜力提供有关血管反应的宝贵临床前信息,这是其他现有方法无法获得的。