Organic solvent nanofiltration (OSN) membranes with enhanced separation performance and excellent structure stability are of great benefit in recovering organic solvent and concentrating molecules in pharmaceutical industry. In this study, we developed a smooth and ultra-thin nanocomposite membrane by incorporating sodium dodecylbenzene sulfonate (SDBS) functionalized molybdenum sulfide (MoS₂) nanosheets into an ultra-thin poly-trimethylsilylpropyne (PTMSP) skin layer on polysulfone (PSf) substrate via a facile solution coating method. The two-dimensional (2D) SDBS-MoS₂ with improved compatibility was employed to provide selective channels for solvent permeation while reducing defect cavities to increase solute rejection. The resulting membrane exhibited a significantly improved methanol permeance of up to 8.38 L m⁻² h⁻¹ bar⁻¹, signifying a noteworthy 56 % increment compared to the pristine membrane. Additionally, the RB rejection increased from 95.05 % to 97.72 %. The as-prepared membrane also demonstrated favorable long-term stability and efficient molecules separation capabilities in the pharmaceutical industry. This work demonstrated that the compatibility and dispersibility of 2D MoS₂ could be improved by adding SDBS, resulting in a SDBS-MoS₂-PTMSP membrane with excellent OSN performance and outstanding long-term stability, making it highly promising for industrial applications.

有机溶剂纳滤（OSN）膜具有增强的分离性能和优异的结构稳定性，对于制药工业中有机溶剂的回收和分子浓缩具有巨大的好处。_{在这项研究中，我们通过将十二烷基苯磺酸钠（SDBS）功能化的硫化钼（MoS 2}）纳米片掺入聚砜（PSf）基底上的超薄聚三甲基硅丙炔（PTMSP）皮层中，开发了一种光滑超薄的纳米复合膜。一种简便的溶液涂覆方法。采用具有改进兼容性的二维 (2D) SDBS-MoS ₂为溶剂渗透提供选择性通道，同时减少缺陷空腔以增加溶质排斥。所得膜的甲醇渗透性显着提高，高达 8.38 L m ^-2 h ^-1 bar ^-1，与原始膜相比，增加了 56%。此外，RB 拒绝率从 95.05% 增加到 97.72%。所制备的膜还在制药行业中表现出良好的长期稳定性和高效的分子分离能力。_{这项工作表明，通过添加SDBS可以改善2D MoS 2}的相容性和分散性，从而使SDBS-MoS ₂ -PTMSP膜具有优异的OSN性能和突出的长期稳定性，使其在工业应用中极具前景。