Physica Medica ( IF 3.3 ) Pub Date : 2023-09-30 , DOI: 10.1016/j.ejmp.2023.102684 Takuya Maeyama 1 , Kiichiro Hayashi 2 , Yusuke Watanabe 3 , Maki Ohara 4 , Seiko Nakagawa 5
A silicon-based three-dimensional dosimeter can be formed in a free shape without a container and deformed because of its flexibility. Several studies have focused on enhancing its radiological characteristics and assessing its applicability as a quality assurance tool for image-guided and adaptive radiation therapy, considering motion and deformation. Here, we applied a fluorescence probe (dihydrorhodamine 6G, DHR6G) to a silicon elastomer as a new radiosensitive compound that converts nonfluorescent into fluorescent dyes using irradiation, and its fluorescence intensity increases linearly with the absorbed dose. In this study, we demonstrated a cost-effective synthesis method and optimized the composition conditions. The results showed that the DHR6G-SE prepared from 2.2 × 10−3 wt% DHR6G, 0.024 wt% pyridine, and a silicone elastomer (SE) (SILPOT TM 184, base/curing agent = 10/1) exhibited a linear increase in fluorescence with radiation exposure within a dose range of 0–8 Gy and a highly stable sensitivity for as long as 64 h. To demonstrate its container-less characteristics, the possibility of dosimetry for low-energy X-rays using DHR6G-SE was investigated.
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
使用二氢罗丹明 6G 开发硅基放射性荧光剂量计
硅基三维剂量计可以形成自由形状,无需容器,并且由于其柔性而可以变形。几项研究的重点是增强其放射学特性,并评估其作为图像引导和自适应放射治疗的质量保证工具的适用性,同时考虑运动和变形。在这里,我们将荧光探针(二氢罗丹明6G,DHR6G)应用于硅弹性体作为一种新型放射敏感化合物,利用辐照将非荧光染料转化为荧光染料,其荧光强度随着吸收剂量线性增加。在这项研究中,我们展示了一种经济有效的合成方法并优化了组成条件。结果表明,由2.2 × 10 -3 wt% DHR6G、0.024 wt%吡啶和有机硅弹性体(SE)(SILPOT TM 184,基质/固化剂= 10/1)制备的DHR6G-SE表现出线性增加辐射剂量范围为 0-8 Gy 的荧光,灵敏度高度稳定,长达 64 小时。为了证明其无容器特性,研究了使用 DHR6G-SE 进行低能 X 射线剂量测定的可能性。