<br>一种基于超分子传感平台的手持式紫外分光光度计检测盐酸甲基苯丙胺装置,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

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一种基于超分子传感平台的手持式紫外分光光度计检测盐酸甲基苯丙胺装置
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.3 ) Pub Date : 2023-10-06 , DOI: 10.1016/j.saa.2023.123499
Xin Ran ₁ , Yanbo Yu ₁ , Hongxing Yang ₁ , Xiaoping Tan ₂ , Zhiyong Ran ₃ , Ruilin Zhang ₄ , Guanben Du ₁ , Long Yang ₁

Affiliation

在吸毒犯罪场所实现毒品检测可以为执法人员提供直接证据。这项研究开发并展示了一种易于使用的手持式传感器，可以在现场快速检测甲基苯丙胺（MA）。手持式紫外分光光度计器件（HUVSD）的核心是 STM32F103 系列单芯片微控制器，它具有一个 32 位微控制器和两个嵌入式 12 位高精度模数转换器（ADC）模块。通过蓝牙-无线传输协议，光谱信息可以显示在手机的 app 中，并且可以根据 410 nm 处的特征峰直观地判断测试样品是否含有盐酸甲基苯丙胺物质。使用容易获得且廉价的诱导化合物 3A 和磷酸盐柱 [5]arene@silver 纳米颗粒（PP5@AgNPs）胶体溶液作为反应物。将PP5@AgNPs胶体溶液与3A混合，在室温下反应，颜色变为灰黑色。颜色变化是由诱导化合物 3A 和 PP5 之间的分子识别诱导的 AgNPs 聚集在 AgNPs 表面引起的。继续加入药物MA后，胶体溶液的颜色再次变黄。这是由于竞争性分子识别的发生，通过分子对接模拟研究了 PP5 和 3A/MA 之间的相互作用。HUVSD 灵敏度高，设备简单，省时，变色可视化，适合现场部署。它只需要一个巴斯德移液器，具有实现快速现场检测的巨大潜力。

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Handheld UV spectrophotometer device for detection of methamphetamine hydrochloride based on supramolecular sensing platform

The realization of drug detection in drug-using crime sites can provide law enforcement officials with direct evidence. This research has developed and demonstrated an easy-to-use handheld sensor that can quickly detect methamphetamine (MA) in the field. The core of the handheld UV spectrophotometer device (HUVSD) is the STM32F103 series of single-chip micro-controller, which has a 32-bit microcontroller and two embedded 12-bit high-precision analog-to-digital converter (ADC) modules. Through Bluetooth-wireless transmission protocol, the spectral information can be displayed in the cell phone's app, and it is possible to visually determine whether the test sample contains methamphetamine hydrochloride substances based on the characteristic peak at 410 nm. The readily available and inexpensive inducible compound 3A and the phosphate pillar[5]arene@silver nanoparticle (PP5@AgNPs) colloidal solution were used as the reactants. The PP5@AgNPs colloidal solution and 3A were mixed and reacted at room temperature, and the color changed to gray-black. The color change was caused by the aggregation of AgNPs induced by the molecular recognition between the induction compound 3A and PP5 on the AgNPs surface. After continuing to add the drug MA, the color of the colloidal solution turned yellow again. This is due to the occurrence of competitive molecular recognition, and the interaction between PP5 and 3A/MA was investigated by molecular docking simulations. The HUVSD has high sensitivity, simple equipment, time-saving, color change visualization and suitable for on-site deployment. It only needs a Pasteur pipette, which has great potential to realize rapid on-site detection.

更新日期：2023-10-06

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