白刺 (Nitraria roborowskii Kom) 的化学分析。UPLC-Q-Orbitrap-MS 及其体内降血脂作用,Chemistry & Biodiversity

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白刺 (Nitraria roborowskii Kom) 的化学分析。UPLC-Q-Orbitrap-MS 及其体内降血脂作用
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2023-10-06 , DOI: 10.1002/cbdv.202300683
Qiangqiang Q Jia ₁ , Zufan F Yang _{1,

2} , Qian Wang _{1,

2} , Qing Zhao _{1,

2} , Yujiao J Jia ₁ , Banghao H Guo ₁ , Xiangyang Y Li _{1,

2} , Wen Wang ₁

Affiliation

白刺 ( Nitraria roborowskii Kom)。（NRK）浆果是霸王科白刺属的果实，已被广泛用作民间药物。现代药理研究证明，白刺具有降血脂、降血糖、免疫调节等作用。然而，关于NRK的化学成分和生物活性还需要更多的研究报道。因此，本研究采用超高效液相色谱-四极轨道质谱系统（UPLC-Q-Orbitrap MS）对NRK浆果中的酚类化合物进行了全面分析和表征。共鉴定出52种酚类物质，且全部为首次报道。此外，在高脂血症小鼠模型中研究了 NRK 浆果提取物的降血脂功效。治疗后，NRK高剂量组显着逆转了总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平。通过脂质组学技术，对 27 种潜在生物标志物进行了表征。通过统计分析方法，其中25例在NRK治疗后出现显着回调。通路分析结果表明NRK可能通过调节甘油磷脂和甘油脂代谢通路发挥治疗作用。这项研究可以提供NRK浆果酚类化合物的第一手资料以及在预防和治疗高脂血症方面的潜在应用。

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Chemical Profiling of Nitraria roborowskii Kom. by UPLC-Q-Orbitrap-MS and Their Hypolipidemic Effects in Vivo

The Nitraria roborowskii Kom. (NRK) berries, as fruits of the genus Nitraria of the Zygophyllceae family, have been widely used as folk medicine. Modern pharmacological research has demonstrated that Nitraria berries had hypolipidemic, hypoglycemic, and immunomodulatory effects. However, more research needs to be reported on the chemical composition and biological activity of NRK. Hence, the phenolic compounds in the NRK berries were comprehensively analyzed and characterized by Ultra Performance Liquid Chromatography-Quadruple-Orbitrap MS system (UPLC-Q-Orbitrap MS) in this study. In total, 52 phenolics were identified, and all were reported for the first time. In addition, the hypolipidemic efficacy of NRK berries extract was studied in the hyperlipidemic mouse model. After treatment, the high dose group of NRK substantially reversed total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels. Through lipidomics technology, 27 potential biomarkers were characterized. And there was a significant callback at 25 of them after NRK treatment by using statistical analysis methods. Pathway analysis results demonstrated that NRK might exert therapeutic effects by regulating glycerophospholipid and glycerolipid metabolism pathways. This study could provide firsthand information on NRK berries for their phenolic compounds and potential application in preventing and treating hyperlipidemia.

更新日期：2023-10-06

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