黄酮类化合物作为糖苷配基保留糖苷酶催化反应：绿色化学的前景,Journal of Agricultural and Food Chemistry

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黄酮类化合物作为糖苷配基保留糖苷酶催化反应：绿色化学的前景
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2023-10-06 , DOI: 10.1021/acs.jafc.3c04389
Michael Kotik ₁ , Natalia Kulik ₁ , Kateřina Valentová ₁

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许多植物性食品中富含类黄酮及其苷。通过保留糖苷水解酶对类黄酮进行（去）糖基化最近引起了基础和应用研究的极大兴趣，包括改变类黄酮糖基化模式的可能性。该领域的研究是由类黄酮苷元与其糖基化对应物之间的物理化学、感官和生物活性特性的显着差异推动的。虽然许多类黄酮苷在自然界中的含量很低，但有些黄酮苷的含量很高，这使得它们很容易成为用于转糖基化的低成本糖基供体。保留糖苷酶可用于合成天然的新型糖苷，以黄酮苷作为糖基供体，作为生物活性实验和分析的标准品。工程糖苷酶也被证明对于使用化学合成的活化糖基供体合成类黄酮糖苷很有价值。本综述概述了类黄酮及其苷的生物活性，并重点介绍了保留糖苷酶在类黄酮苷中的应用，在去糖基化或转糖基反应中充当底物、产物或糖基供体。

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Flavonoids as Aglycones in Retaining Glycosidase-Catalyzed Reactions: Prospects for Green Chemistry

Flavonoids and their glycosides are abundant in many plant-based foods. The (de)glycosylation of flavonoids by retaining glycoside hydrolases has recently attracted much interest in basic and applied research, including the possibility of altering the glycosylation pattern of flavonoids. Research in this area is driven by significant differences in physicochemical, organoleptic, and bioactive properties between flavonoid aglycones and their glycosylated counterparts. While many flavonoid glycosides are present in nature at low levels, some occur in substantial quantities, making them readily available low-cost glycosyl donors for transglycosylations. Retaining glycosidases can be used to synthesize natural and novel glycosides, which serve as standards for bioactivity experiments and analyses, using flavonoid glycosides as glycosyl donors. Engineered glycosidases also prove valuable for the synthesis of flavonoid glycosides using chemically synthesized activated glycosyl donors. This review outlines the bioactivities of flavonoids and their glycosides and highlights the applications of retaining glycosidases in the context of flavonoid glycosides, acting as substrates, products, or glycosyl donors in deglycosylation or transglycosylation reactions.

更新日期：2023-10-06

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