A multi-functional drug delivery nanosystem release of TLR-7 immunostimulant and OKT3 induced efficient cancer immunotherapy,Photodiagnosis and Photodynamic Therapy

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A multi-functional drug delivery nanosystem release of TLR-7 immunostimulant and OKT3 induced efficient cancer immunotherapy
Photodiagnosis and Photodynamic Therapy ( IF 3.1 ) Pub Date : 2023-10-04 , DOI: 10.1016/j.pdpdt.2023.103834
RuYan Li ₁ , Xu Huang ₁ , Xu Li ₁ , HaiLong Liu ₁ , JiaHong Zhou ₁ , Jian Shen ₂

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Immunotherapy has some shortcomings such as off-target toxicity, treatment time and poor immunogenicity, which limit its therapeutic effect. Nanomaterials are particularly attractive in immunotherapy due to their drug delivery capabilities. Nano drug delivery system loaded with Toll-like receptor (TLR) agonist imiquimod (IMQ) and CD3 immune antibody OKT3 is constructed by using polydopamine (PDA) and CaCO3. While PDA-IMQ@CaCO3-OKT3 (PICO NPs) drug delivery system has the advantages of high biocompatibility, low toxicity, degradability. Antitumor studies in vitro and in vivo have shown that the system can effectively inhibit the proliferation of mouse breast cancer cells and the activity of Regulatory T Cells (Tregs), activate immunogenic cell death (ICD), and enhance the activity of antigen-presenting cells (APCs). Effectively eliminate tumor immunosuppression and fully activate immune function.

中文翻译：

TLR-7 免疫刺激剂和 OKT3 的多功能药物递送纳米系统释放诱导的高效癌症免疫治疗

免疫治疗存在脱靶毒性、治疗时间长和免疫原性差等缺点，限制了其治疗效果。纳米材料因其药物递送能力而在免疫治疗中特别有吸引力。利用聚多巴胺（PDA）和 CaCO3 构建载有 Toll 样受体（TLR）激动剂咪喹莫特（IMQ）和 CD3 免疫抗体 OKT3 的纳米药物递送系统。而 PDA-IMQ@CaCO3-OKT3 （PICO NPs）药物递送系统具有高生物相容性、低毒性、可降解性等优点。体外和体内抗肿瘤研究表明，该系统可有效抑制小鼠乳腺癌细胞的增殖和调节性 T 细胞（Treg）的活性，激活免疫原性细胞死亡（ICD），并增强抗原呈递细胞（APC）的活性。有效消除肿瘤免疫抑制，充分激活免疫功能。

更新日期：2023-10-04

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