<br>ILC2和TH2细胞协同驱除肠道蠕虫寄生虫,Nature Reviews Immunology

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ILC2和TH2细胞协同驱除肠道蠕虫寄生虫
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2023-10-05 , DOI: 10.1038/s41577-023-00942-1
Dietmar M W Zaiss _{1,

2,

3} , Edward J Pearce _{4,

5} , David Artis _{6,

7,

8,

9} , Andrew N J McKenzie ₁₀ , Christoph S N Klose ₁₁

Affiliation

Department of Immune Medicine, University Regensburg, Regensburg, Germany.
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.
Bloomberg Kimmel Institute for Cancer Immunotherapy, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, MD, USA.
Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Friedman Center for Nutrition and Inflammation, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
MRC Laboratory of Molecular Biology, Cambridge, UK.
Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

2 型免疫反应形成针对肠道蠕虫感染的关键防御。近年来，小鼠模型揭示了第 2 组先天淋巴细胞和辅助 T 2 细胞在针对肠道蠕虫的 2 型免疫反应中具有共同且独特的功能。两种细胞类型在感染部位使用相似的先天效应功能，而每种细胞群在感染的不同阶段具有不同的作用。在这篇文章中，我们回顾了第 2 类先天淋巴细胞和辅助性 T 细胞 2 相互协作的基本机制，并提出了蠕虫感染过程中这些细胞类型之间相互作用的总体模型。

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更新日期：2023-10-05

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