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Functional Integration of DNA and Peptide-Based Supramolecular Nanoassemblies for Cancer Therapy
Accounts of Materials Research ( IF 14.0 ) Pub Date : 2023-09-29 , DOI: 10.1021/accountsmr.3c00112 Yuhang Dong 1 , Yunhua Guo 1 , Wenzhe Song 1 , Guangjun Nie 2 , Feng Li 1
Accounts of Materials Research ( IF 14.0 ) Pub Date : 2023-09-29 , DOI: 10.1021/accountsmr.3c00112 Yuhang Dong 1 , Yunhua Guo 1 , Wenzhe Song 1 , Guangjun Nie 2 , Feng Li 1
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Supramolecular assembly is a process in which monomers spontaneously construct highly organized and advanced multimolecular assembly systems and thus has become one of the underlying molecular basis of living system. DNA and peptides, as two of the most critical biomacromolecules, rely on intermolecular recognition-based supramolecular assembly to participate in various life activities. Intracellular delivery of functional nucleic acids and peptides has been widely explored for cancer treatment by reprogramming cell function and fate. However, nucleic acids and peptides suffer from the issues of instability and poor bioavailability. In recent years, DNA and peptides have been widely explored as controllable and functional building blocks for the construction of supramolecular nanoassemblies. DNA and peptide-based nanoassemblies have the capability of protecting DNA and peptide monomers from degradation in plasma and to facilitate their cellular uptake. Moreover, the elaborately designed nucleotide and amino acid sequences can be integrated into building blocks, thus endowing supramolecular nanoassemblies with preset structures and functions for application in specific scenarios. Compared with synthetic polymers, the fascinating properties including sequence programmability, structure designability, function customizability, and predicable stimuli-responsiveness combined endowed DNA and peptide nanoassemblies with programmable supramolecular assembly superiority, which facilitates spatiotemporally controllable assembly and release of drugs.
中文翻译：
DNA 和基于肽的超分子纳米组件的功能整合用于癌症治疗
超分子组装是单体自发构建高度组织化、先进的多分子组装系统的过程，已成为生命系统的潜在分子基础之一。DNA和肽作为两种最关键的生物大分子，依靠基于分子间识别的超分子组装来参与各种生命活动。通过重新编程细胞功能和命运，功能性核酸和肽的细胞内递送已被广泛探索用于癌症治疗。然而，核酸和肽存在不稳定和生物利用度差的问题。近年来，DNA和肽作为构建超分子纳米组件的可控且功能性的构建模块得到了广泛的探索。基于 DNA 和肽的纳米组件能够保护 DNA 和肽单体免于在血浆中降解并促进其细胞摄取。此外，精心设计的核苷酸和氨基酸序列可以集成到构建块中，从而赋予超分子纳米组装体预设的结构和功能，以应用于特定场景。与合成聚合物相比，DNA和肽纳米组装体具有序列可编程性、结构可设计性、功能可定制性和可预测刺激响应性等令人着迷的特性，赋予其可编程超分子组装优势，有利于药物的时空可控组装和释放。
更新日期：2023-09-29
中文翻译：
DNA 和基于肽的超分子纳米组件的功能整合用于癌症治疗
超分子组装是单体自发构建高度组织化、先进的多分子组装系统的过程，已成为生命系统的潜在分子基础之一。DNA和肽作为两种最关键的生物大分子，依靠基于分子间识别的超分子组装来参与各种生命活动。通过重新编程细胞功能和命运，功能性核酸和肽的细胞内递送已被广泛探索用于癌症治疗。然而，核酸和肽存在不稳定和生物利用度差的问题。近年来，DNA和肽作为构建超分子纳米组件的可控且功能性的构建模块得到了广泛的探索。基于 DNA 和肽的纳米组件能够保护 DNA 和肽单体免于在血浆中降解并促进其细胞摄取。此外，精心设计的核苷酸和氨基酸序列可以集成到构建块中，从而赋予超分子纳米组装体预设的结构和功能，以应用于特定场景。与合成聚合物相比，DNA和肽纳米组装体具有序列可编程性、结构可设计性、功能可定制性和可预测刺激响应性等令人着迷的特性，赋予其可编程超分子组装优势，有利于药物的时空可控组装和释放。
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