<br>基因与光热联合疗法：原理、材料和放大抗癌干预,Small

当前位置： X-MOL 学术 › Small › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

基因与光热联合疗法：原理、材料和放大抗癌干预
Small ( IF 13.0 ) Pub Date : 2023-09-29 , DOI: 10.1002/smll.202307078
Fang Tang _{1,

2} , Aixiang Ding ₁ , Yao Xu ₁ , Yingsong Ye ₁ , Lin Li _{1,

2,

3} , Rongjun Xie ₄ , Wei Huang _{1,

2,

3}

Affiliation

基因疗法 (GT) 和光热疗法 (PTT) 已成为癌症治疗化疗和放疗的有前景的替代方案，具有非侵入性和减少副作用。然而，它们作为独立治疗的功效是有限的。 GT反应速度慢，而PTT仅限于局部肿瘤消融。 GT 和 PTT 的融合，即 GT-PTT，由光热基因纳米载体促进，引起了各个学科的广泛关注。在这种综合方法中，GT 通过使细胞对热的反应敏感而与 PTT 相互作用，而 PTT 通过改善基因易位、解包和表达而使 GT 受益。因此，这种整合为癌症治疗提供了一个独特的机会，可以快速反应并提高疗效。过去几年，GT-PTT的发展得到了广泛的努力，取得了显着的成就，并从实验室到潜在的临床应用取得了快速进展。这篇全面的综述概述了 GT-PTT 的最新进展，包括协同机制、材料系统、成像引导治疗和抗癌应用。它还探讨了这个新兴领域的挑战和未来前景。通过提出实施 GT-PTT 增强癌症治疗的创新想法和见解，本综述旨在激发这一前景广阔的研究领域取得进一步进展。

"点击查看英文标题和摘要"

Gene and Photothermal Combination Therapy: Principle, Materials, and Amplified Anticancer Intervention

Gene therapy (GT) and photothermal therapy (PTT) have emerged as promising alternatives to chemotherapy and radiotherapy for cancer treatment, offering noninvasiveness and reduced side effects. However, their efficacy as standalone treatments is limited. GT exhibits slow response rates, while PTT is confined to local tumor ablation. The convergence of GT and PTT, known as GT-PTT, facilitated by photothermal gene nanocarriers, has attracted considerable attention across various disciplines. In this integrated approach, GT reciprocates PTT by sensitizing cellular response to heat, while PTT benefits GT by improving gene translocation, unpacking, and expression. Consequently, this integration presents a unique opportunity for cancer therapy with rapid response and improved effectiveness. Extensive efforts over the past few years have been dedicated to the development of GT-PTT, resulting in notable achievements and rapid progress from the laboratory to potential clinical applications. This comprehensive review outlines recent advances in GT-PTT, including synergistic mechanisms, material systems, imaging-guided therapy, and anticancer applications. It also explores the challenges and future prospects in this nascent field. By presenting innovative ideas and insights into the implementation of GT-PTT for enhanced cancer therapy, this review aims to inspire further progress in this promising area of research.

更新日期：2023-09-29

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11