Herein, a novel one-pot strategy combining an enzyme and visible-light catalysis for the synthesis of quinazoline derivatives from 2-aminobenzylamine and methyl benzoylformate is described for the first time. The reaction comprises enzyme-catalyzed hydrolysis, visible-light-activated decarboxylation, and oxidation cyclization. A series of reactions between 2-aminobenzylamine and different methyl benzoylformates afforded the corresponding products. This strategy was successfully applied to the reaction of 2-aminobenzamide and o-phenylenediamine with methyl benzoylformate. This method has the advantages of not requiring additional additives or transition metals, providing an efficient and environmentally friendly approach for synthesizing quinazoline compounds.

在此，首次描述了一种结合酶和可见光催化的新型一锅法策略，用于从 2-氨基苄胺和苯甲酰甲酸甲酯合成喹唑啉衍生物。该反应包括酶催化水解、可见光激活脱羧和氧化环化。2-氨基苄胺和不同的苯甲酰甲酸甲酯之间的一系列反应得到了相应的产物。该策略成功应用于2-氨基苯甲酰胺和邻苯二胺与苯甲酰甲酸甲酯的反应。该方法不需要额外的添加剂或过渡金属，为喹唑啉类化合物的合成提供了一种高效、环保的方法。