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Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity
Results in Chemistry ( IF 2.5 ) Pub Date : 2023-09-29 , DOI: 10.1016/j.rechem.2023.101141
G. Sathiyaraj , A. Vignesh , K. Priyanka , K.S. Neethu , D. Badhmapriya , K. Preethi , N. Dharmaraj , M.V. Kaveri

This work describes the fabrication of a carbazole derivative 1 namely (E)-5-(diethylamino)-2-((9-ethyl-9H-carbazol-3-yl)imino)methyl)phenol(1) based colorimetric probe for the selective detection of copper (II) ions. The as-prepared carbazole derivative was characterized using various spectral techniques including UV–visible absorption, Emission, FT-IR, 1H NMR, 13C NMR and mass spectra. The colorimetric chemosensing potential of the synthesized carbazole derivative 1 to detect Cu2+ ions in a solution of different cations at different emission wavelengths based on photo-induced electron transfer (PET) mechanism was undertaken. In addition, the probe 1 showed significant DPPH scavenging activity. Antimicrobial and anti-inflammatory activities of the carbazole derivative 1 were also assessed. The selectivity of probe 1 towards Cu2+ ions could be exploited to reduce copper induced toxicity.



中文翻译:

多功能应用的 3-氨基-9-乙基咔唑支架的构建:铜(II)离子化学传感器以及抗菌、抗氧化和抗炎活性

这项工作描述了基于 (E)-5-(二乙氨基)-2-((9-乙基-9H-咔唑-3-基)亚氨基)甲基)苯酚(1) 的咔唑衍生物 1 的比色探针制备选择性检测铜 (II) 离子。使用各种光谱技术对所制备的咔唑衍生物进行了表征,包括紫外-可见吸收、发射、FT-IR、1 H NMR、13 C NMR 和质谱。基于光诱导电子转移(PET)机制,对合成的咔唑衍生物1的比色化学传感电位进行了检测不同阳离子溶液中不同发射波长的Cu 2+离子。另外,探头1表现出显着的 DPPH 清除活性。还评估了咔唑衍生物1的抗菌和抗炎活性。可以利用探针1对Cu 2+离子的选择性来降低铜诱导的毒性。

更新日期:2023-09-29
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