Colonoscopy is considered the standard procedure for early detection and prevention of colorectal cancer. Adequate bowel cleansing is an important determinant of the efficacy of colonoscopy screening. Currently, there is no standard method of bowel preparation for patients with chronic constipation. The aim was to access the rate of adequate bowel cleansing achieved using split-dose polyethylene glycol electrolyte lavage solution (PEG-ELS) plus lubiprostone in comparison with split-dose PEG-ELS alone. A single-centre, endoscopist-blinded, randomized controlled trial was conducted. Seventy-eight constipated patients aged 18–75 years who were indicated for colonoscopy in the gastroenterology unit of Srinagarind Hospital, Khon Kaen University, between February 2020 and February 2021 were randomly allocated to receive either split-dose PEG-ELS in combination with lubiprostone (N = 39) or split-dose PEG-ELS alone (N = 39) before colonoscopy. Adequate bowel cleansing was defined as an Ottawa bowel preparation score ≤ 7. The rate of adequate bowel cleansing was comparable between the PEG-ELS plus lubiprostone group and the PEG-ELS alone group (50% vs. 52.9%, p value = 0.81) with a relative risk of 1.13 (95% CI = 0.43–2.91). There were no significant differences in adenoma detection rate (41.2% vs. 35.3%, p value = 0.62), adverse events, acceptance, compliance, or patient satisfaction between the 2 groups. No additional benefit to successful bowel preparation was achieved by the combination of lubiprostone and PEG-ELS in chronic constipation patients undergoing colonoscopy.

结肠镜检查被认为是早期发现和预防结直肠癌的标准程序。充分的肠道清洁是结肠镜筛查效果的重要决定因素。目前，慢性便秘患者尚无标准的肠道准备方法。目的是了解使用分次剂量聚乙二醇电解质灌洗液 (PEG-ELS) 加鲁比前列酮与单独分次剂量 PEG-ELS 相比所实现的充分肠道清洁率。进行了一项单中心、内窥镜盲法、随机对照试验。2020 年 2 月至 2021 年 2 月期间，78 名年龄在 18-75 岁之间的便秘患者被随机分配到孔敬大学斯利那加林医院胃肠科接受结肠镜检查，接受分次剂量 PEG-ELS 联合鲁比前列酮治疗（ N = 39) 或在结肠镜检查前单独分次剂量 PEG-ELS (N = 39)。充分的肠道清洁被定义为渥太华肠道准备评分 ≤ 7。PEG-ELS 加鲁比前列酮组和单独 PEG-ELS 组的充分肠道清洁率相当（50% vs. 52.9%，p值 = 0.81）相对风险为 1.13 (95% CI = 0.43–2.91)。两组之间的腺瘤检出率（41.2% vs. 35.3%， p值 = 0.62）、不良事件、接受度、依从性或患者满意度没有显着差异。在接受结肠镜检查的慢性便秘患者中，鲁比前列酮和 PEG-ELS 的联合治疗并未对成功的肠道准备带来额外的益处。