基于响应性纳米载体的纳米药物用于癌症治疗,Advanced Therapeutics

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基于响应性纳米载体的纳米药物用于癌症治疗
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2023-09-26 , DOI: 10.1002/adtp.202300223
Zhi‐Shan Liu ₁ , Jing Wen ₁ , Chu‐Yu Huang ₁ , Pei‐Wen Zhang ₁ , Ying‐Ling Miao ₁ , Hong Cheng ₂ , Shi‐Ying Li ₁

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近年来，纳米技术在药物设计中得到广泛应用，在肿瘤治疗中展现出巨大的潜力和优势。然而，大多数传统纳米药物的应用仍然受到载药量低、靶向能力差、全身毒性等问题的限制。基于肿瘤微环境的特点，大量研究表明，构建刺激响应性纳米载体可以通过提高递送效率、减少副作用、增强靶向性等方式有效解决上述问题。响应性纳米载体的一个显着特征是它们可以在刺激下在特定位点释放并激活药物，包括内部刺激（例如pH、活性氧（ROS）、谷胱甘肽（GSH）、酶、缺氧、三磷酸腺苷（ATP））等）和外部刺激（例如光、热、超声波等）。值得注意的是，了解各种反应途径可以使研究人员有效地设计用于肿瘤治疗的反应性纳米载体。在此，本综述重点关注纳米载体用于肿瘤治疗的刺激响应策略。此外，还讨论了响应性纳米载体在协同肿瘤治疗中的作用。本综述的期望是为实用有效的响应性纳米载体的设计提供思路。

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Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

Nanotechnology has been widely used in drug design in recent years, showing great potential and advantages in tumor therapy. However, the application of most traditional nanomedicines is still limited by low drug loading rate, poor targeting ability, and systemic toxicity. Based on the characteristics of tumor microenvironments, numerous studies indicate that the construction of stimuli-responsive nanocarriers can effectively solve the above problems by improving delivery efficiency, reducing side effects, and enhancing targeting. A significant feature of responsive nanocarriers is that they can release and activate drugs at specific sites under stimulus, including internal stimuli (e.g., pH, reactive oxygen species (ROS), glutathione (GSH), enzyme, hypoxia, adenosine-triphosphate (ATP), etc.) and external stimuli (e.g., light, thermo, ultrasound, etc.). Of note, learning about various pathways of responses can enable researchers to effectively design responsive nanocarriers for tumor therapy. Herein, this review focuses on the stimuli-responsive strategies of nanocarriers for tumor therapy. In addition, the role of responsive nanocarriers in synergistic tumor therapy is also discussed. The expectation of this review is to provide ideas for the design of practical and effective responsive nanocarriers.

更新日期：2023-09-26

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