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A regioselective synthesis of 5-difluoromethyl- and 7-difluoromethyl-substituted pyrazolo[1,5-a]pyrimidines
Chemistry of Heterocyclic Compounds ( IF 1.4 ) Pub Date : 2023-09-28 , DOI: 10.1007/s10593-023-03236-5
Valery S. Tolkunov , Andrew S. Tolkunov , Olga V. Smirnova , Sergei V. Tolkunov

The cyclocondensation of 3,4-substituted 5-aminopyrazoles with unsymmetrical 1,3-dicarbonyl compounds containing the difluoromethyl group in acetic acid led to 7-difluoromethylpyrazolo[1,5-a]pyrimidines, whereas 5-difluoromethylpyrazolo[1,5-a]pyrimidine derivatives were predominantly formed in trifluoroacetic acid.



中文翻译:

5-二氟甲基和7-二氟甲基取代的吡唑并[1,5-a]嘧啶的区域选择性合成

3,4-取代的5-氨基吡唑与含有二氟甲基的不对称1,3-二羰基化合物在乙酸中环缩合生成7-二氟甲基吡唑并[1,5- a ]嘧啶,而5-二氟甲基吡唑并[1,5- a] ]嘧啶衍生物主要在三氟乙酸中形成。

更新日期:2023-09-28
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