Nano Research ( IF 9.5 ) Pub Date : 2023-09-28 , DOI: 10.1007/s12274-023-6170-4
Jie Meng , Xuechun Hu , Tao Wen , Tao Wang , Jian Liu , Haiyan Xu
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Carbon nanotubes (CNTs) have been largely investigated in various biomedical fields on the basis of their excellent physical properties and drug delivery performance. However, application capacities of CNTs in blood-contacting medical devices are given due attention though there have been increasingly accumulated experimental data showing promising potentials. Herein, we collected and showed research evidence that strong interactions of CNTs to plasm proteins are attractive and valuable features holding great application potentials for medical devices and implants used in blood-contacting environments, while blood compatibility has been a big challenge faced by this kind of devices. This review introduces the strong and nonspecific plasm protein adsorptions of CNTs due to their high purity of carbon composition and nanostructures, followed by discussions on the implication of these interactions to blood coagulation and complement activation, aiming to sort out and provide insights into the application potentials of CNTs in blood-contacting medical devices and implants in the context of anti-thrombosis and blood purification.
中文翻译:
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碳纳米管与血浆蛋白的相互作用及其在血液接触医疗器械中的应用潜力
碳纳米管(CNT)凭借其优异的物理性能和药物输送性能,在各个生物医学领域得到了广泛的研究。然而,尽管越来越多的实验数据显示出碳纳米管在血液接触医疗器械中的应用潜力,但碳纳米管在血液接触医疗器械中的应用能力受到了应有的关注。在此,我们收集并展示了研究证据,表明碳纳米管与血浆蛋白的强相互作用是有吸引力且有价值的特征,对于血液接触环境中使用的医疗器械和植入物具有巨大的应用潜力,而血液相容性一直是此类材料面临的一大挑战。设备。这篇综述介绍了碳纳米管由于其高纯度的碳成分和纳米结构而具有很强的非特异性血浆蛋白吸附作用,