The purpose of this study was to identify the effect of antihypertensive medication on risks of open-angle glaucoma (OAG) among patients diagnosed with hypertension (HTN). A total of 5,195 patients, who were diagnosed with HTN between January 1, 2006 and December 31, 2015, and subsequently diagnosed with OAG, were selected for analysis. For each OAG patient, 5 non-glaucomatous, hypertensive controls were matched (n = 25,975) in hypertension diagnosis date, residential area, insurance type and economic status. Antihypertensive medications were stratified into 5 types: angiotensin converting enzyme inhibitor (ACEi), angiotensin receptor blockers (ARB), calcium channel blockers (CCB), β-blockers and diuretics. Relative risks were calculated. After adjusting for age, sex, body mass index, lifestyle, comorbidities, blood pressure (BP), follow-up duration, and use of other types of antihypertensive drugs, ARB and CCB were found to slightly increase OAG risks (RR 1.1087 (95% CI 1.0293–1.1942); 1.0694 (1.0077–1.1349), respectively). Combinations of ARB with diuretics (1.0893 (1.0349–1.1466)) and CCB (1.0548 (1.0122–1.0991)) also increased OAG risks. The risks for OAG were found to increase by antihypertensive medication use, but the effects appeared to be small. Further studies are necessary to identify the associations of increased BP, medication and therapeutic effect with OAG.

本研究的目的是确定抗高血压药物对诊断为高血压 （HTN） 的患者开角型青光眼 （OAG） 风险的影响。共选择了 5,195 例在 2006 年 1 月 1 日至 2015 年 12 月 31 日期间被诊断患有 HTN 并随后被诊断为 OAG 的患者进行分析。对于每位 OAG 患者，在高血压诊断日期、居住地区、保险类型和经济状况方面匹配了 5 名非青光眼高血压对照 （n = 25,975）。将降压药分为血管紧张素转换酶抑制剂 （ACEi） 、血管紧张素受体阻滞剂 （ARB） 、钙通道阻滞剂 （CCB） 、β阻滞剂和利尿剂 5 种类型。计算相对风险。在调整了年龄、性别、体重指数、生活方式、合并症、血压 （BP）、随访持续时间和其他类型的抗高血压药物的使用后，发现 ARB 和 CCB 略微增加了 OAG 风险 （分别为 RR 1.1087 （95% CI 1.0293–1.1942）;1.0694 （1.0077–1.1349）。ARB 与利尿剂 （1.0893 （1.0349–1.1466）） 和 CCB （1.0548 （1.0122–1.0991）） 的组合也增加了 OAG 风险。研究发现，使用抗高血压药物会增加 OAG 的风险，但效果似乎很小。需要进一步的研究来确定血压升高、药物和治疗效果与 OAG 的关联。