Galangin is an important flavonoid with natural activity, that is abundant in galangal and propolis. Currently, various biological activities of galangin have been disclosed, including anti-inflammation, antibacterial effect, anti-oxidative stress and aging, anti-fibrosis, and antihypertensive effect. Based on the above bioactivities, more and more attention has been paid to the role of galangin in neurodegenerative diseases, rheumatoid arthritis, osteoarthritis, osteoporosis, skin diseases, and cancer. In this paper, the natural sources, pharmacokinetics, bioactivities, and therapeutic potential of galangin against various diseases were systematically reviewed by collecting and summarizing relevant literature. In addition, the molecular mechanism and new preparation of galangin in the treatment of related diseases are also discussed, to broaden the application prospect and provide reference for its clinical application. Furthermore, it should be noted that current toxicity and clinical studies of galangin are insufficient, and more evidence is needed to support its possibility as a functional food.

中文翻译：

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高良姜素：一种食品来源的黄酮类化合物，具有治疗多种疾病的潜力


高良姜素是一种重要的具有天然活性的黄酮类化合物，在高良姜和蜂胶中含量丰富。目前，高良姜素的多种生物活性已被公开，包括抗炎、抗菌、抗氧化应激和衰老、抗纤维化、抗高血压等。基于上述生物活性，高良姜素在神经退行性疾病、类风湿性关节炎、骨关节炎、骨质疏松症、皮肤病、癌症等方面的作用越来越受到重视。本文通过收集和总结相关文献，系统综述了高良姜素的天然来源、药代动力学、生物活性以及对多种疾病的治疗潜力。此外，还探讨了高良姜素治疗相关疾病的分子机制和新制剂，以拓宽其应用前景，为其临床应用提供参考。此外，值得注意的是，目前高良姜素的毒性和临床研究还不够充分，还需要更多的证据来支持其作为功能食品的可能性。