Transition-Metal-Catalyzed Silylation and Borylation of C–H Bonds for the Synthesis and Functionalization of Complex Molecules,Chemical Reviews

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Transition-Metal-Catalyzed Silylation and Borylation of C–H Bonds for the Synthesis and Functionalization of Complex Molecules
Chemical Reviews ( IF 51.4 ) Pub Date : 2023-09-26 , DOI: 10.1021/acs.chemrev.3c00207
Isaac F Yu ₁ , Jake W Wilson ₁ , John F Hartwig ₁

Affiliation

The functionalization of C–H bonds in organic molecules containing functional groups has been one of the holy grails of catalysis. One synthetically important approach to the diverse functionalization of C–H bonds is the catalytic silylation or borylation of C–H bonds, which enables a broad array of downstream transformations to afford diverse structures. Advances in both undirected and directed methods for the transition-metal-catalyzed silylation and borylation of C–H bonds have led to their rapid adoption in early-, mid-, and late-stage of the synthesis of complex molecules. In this Review, we review the application of the transition-metal-catalyzed silylation and borylation of C–H bonds to the synthesis of bioactive molecules, organic materials, and ligands. Overall, we aim to provide a picture of the state of art of the silylation and borylation of C–H bonds as applied to the synthesis and modification of diverse architectures that will spur further application and development of these reactions.

中文翻译：

过渡金属催化的 C-H 键的硅烷化和硼基化用于复杂分子的合成和功能化

含有官能团的有机分子中C-H键的官能化一直是催化的圣杯之一。C-H键多样化功能化的一种综合重要方法是C-H键的催化甲硅烷基化或硼基化，这使得广泛的下游转化能够提供不同的结构。过渡金属催化的 C-H 键硅烷化和硼基化的非定向和定向方法的进步使其在复杂分子合成的早期、中期和后期得到了快速采用。在这篇综述中，我们综述了过渡金属催化的C-H键硅烷化和硼基化在生物活性分子、有机材料和配体合成中的应用。总的来说，我们的目标是提供一幅 C-H 键的甲硅烷基化和硼基化的最新技术图景，应用于不同结构的合成和修饰，这将促进这些反应的进一步应用和发展。

更新日期：2023-09-26

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