<br>细菌菌毛 Caf1 的聚合物和材料科学,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

细菌菌毛 Caf1 的聚合物和材料科学
Biomaterials Science ( IF 5.8 ) Pub Date : 2023-09-26 , DOI: 10.1039/d3bm01075a
David A Fulton ₁ , Gema Dura _{1,

2} , Daniel T Peters ₃

Affiliation

菌毛是位于细菌表面的长丝状聚合蛋白质结构。菌毛的生物合成和功能通常与致病性有关，几十年来一直是一个富有成效的研究课题。进化压力确保菌毛具有对细菌有利的独特结构和机械特性。这些特性也很难用众所周知的合成纤维和天然纤维来设计，这提出了一个有趣的问题：我们能否以有用的方式利用细菌菌毛的独特特性？初步工作已着手通过使用荚膜抗原片段 1 (Caf1) 来探索这个问题，荚膜抗原片段 1 是鼠疫耶尔森氏菌自然表达的菌毛。这些纤维已经进化到“保护”细菌免受感染宿主免疫系统的侵害，因此本质上具有相当的生物惰性。然而，Caf1 非常适合结构诱变，从而可以掺入有用的生物活性功能并调节纤维的机械性能。其高产重组合成还确保了充足的聚合物可用于推动开发。这些有利的特征使 Caf1 成为开发基于细菌菌毛的新型聚合物和材料的原型。在这里，我们介绍了这个新领域的最新进展，并展望了这种有前途的生物聚合物的未来可能性。

"点击查看英文标题和摘要"

The polymer and materials science of the bacterial fimbriae Caf1

Fimbriae are long filamentous polymeric protein structures located upon the surface of bacteria. Often implicated in pathogenicity, the biosynthesis and function of fimbriae has been a productive topic of study for many decades. Evolutionary pressures have ensured that fimbriae possess unique structural and mechanical properties which are advantageous to bacteria. These properties are also difficult to engineer with well-known synthetic and natural fibres, and this has raised an intriguing question: can we exploit the unique properties of bacterial fimbriae in useful ways? Initial work has set out to explore this question by using Capsular antigen fragment 1 (Caf1), a fimbriae expressed naturally by Yersina pestis. These fibres have evolved to ‘shield’ the bacterium from the immune system of an infected host, and thus are rather bioinert in nature. Caf1 is, however, very amenable to structural mutagenesis which allows the incorporation of useful bioactive functions and the modulation of the fibre's mechanical properties. Its high-yielding recombinant synthesis also ensures plentiful quantities of polymer are available to drive development. These advantageous features make Caf1 an archetype for the development of new polymers and materials based upon bacterial fimbriae. Here, we cover recent advances in this new field, and look to future possibilities of this promising biopolymer.

更新日期：2023-09-26

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文本刊介绍/投稿指南