Analytical and preparative chiral supercritical fluid chromatography resolutions using crown ether-derived column,Chirality

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Analytical and preparative chiral supercritical fluid chromatography resolutions using crown ether-derived column
Chirality ( IF 2.8 ) Pub Date : 2023-09-22 , DOI: 10.1002/chir.23621
Lei Yue ₁ , Larry Miller ₂ , John Reilly ₃

Affiliation

In this study, crown ether-derived column Crownpak® CR-I (+) was evaluated under SFC conditions using 12 primary amines, and the chromatographic results were compared against eight immobilized polysaccharide-based columns. Crownpak® CR-I (+) achieved a significantly higher success rate. It was found that the addition of 5% water to the modifier dramatically improved the peak shape for chiral separation of primary amines on Crownpak® CR-I (+). The first reported preparative SFC separations on Crownpak® CR-I (+) are shown, offering a new approach for the preparative resolution of primary amines. The case studies demonstrate that Crownpak® CR-I (+) is a very useful column in the chiral separation of challenging compounds that contain a primary amine group in the pharmaceutical industry.

中文翻译：

使用冠醚衍生色谱柱进行分析和制备手性超临界流体色谱分辨率

在本研究中，使用 12 种伯胺在 SFC 条件下对冠醚衍生色谱柱 Crownpak® CR-I (+) 进行了评估，并将色谱结果与八种固定化多糖色谱柱进行了比较。 Crownpak® CR-I (+) 取得了显着更高的成功率。结果发现，在改性剂中添加 5% 的水可显着改善 Crownpak® CR-I (+) 上伯胺手性分离的峰形。首次报道了在 Crownpak® CR-I (+) 上进行制备型 SFC 分离，为伯胺的制备型拆分提供了一种新方法。案例研究表明，Crownpak® CR-I (+) 是一种非常有用的色谱柱，可用于制药行业中含有伯胺基团的挑战性化合物的手性分离。

更新日期：2023-09-22

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