Synthetic Approaches to Ribosyl Adenosine 5′,5′′-Diphosphate Fragment of Poly(ADP-ribose),European Journal of Organic Chemistry

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Synthetic Approaches to Ribosyl Adenosine 5′,5′′-Diphosphate Fragment of Poly(ADP-ribose)
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2023-09-23 , DOI: 10.1002/ejoc.202300875
Rui Hagino ₁ , Keita Mozaki ₂ , Naoko Komura ₃ , Akihiro Imamura ₂ , Hideharu Ishida ₂ , Hiromune Ando ₃ , Hide-Nori Tanaka ₄

Affiliation

Two synthetic approaches to the poly(ADP-ribose) fragment via a common precursor were successfully developed. The first approach employed an indirect method that involved stepwise assembly of the ribosyl adenosine framework by O-ribofuranosylation and subsequent N-glycosylation. The second approach featured direct O-ribofuranosylation of a known 6-chloropurine riboside acceptor. The precursor was converted into a conjugation-ready building block for oligo(ADP-ribose) synthesis.

中文翻译：

聚(ADP-核糖)核糖基腺苷5′,5′′-二磷酸片段的合成方法

成功开发了两种通过共同前体合成聚（ADP-核糖）片段的方法。第一种方法采用间接方法，涉及通过O-呋喃核糖基化和随后的N-糖基化逐步组装核糖基腺苷框架。第二种方法的特点是对已知的 6-氯嘌呤核苷受体进行直接O-呋喃核糖基化。该前体被转化为用于寡聚（ADP-核糖）合成的缀合结构单元。

更新日期：2023-09-23

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