当前位置：
X-MOL 学术
›
Chem. Bio. Drug Des.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Structure-based biological investigations on ruthenium complexes containing 2,2′-bipyridine ligands and their applications in photodynamic therapy as a potential photosensitizer
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2023-09-18 , DOI: 10.1111/cbdd.14341 Naveen Y. Puttaswamy 1 , Pranami Mahanta 2 , Pranjit Sarma 2 , Chitrani Medhi 2 , Sanaa Mohammed Abdu Kaid 1 , Byrappa Kullaiah 1 , Debajani Basumatary 2 , Babu A. Manjasetty 1
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2023-09-18 , DOI: 10.1111/cbdd.14341 Naveen Y. Puttaswamy 1 , Pranami Mahanta 2 , Pranjit Sarma 2 , Chitrani Medhi 2 , Sanaa Mohammed Abdu Kaid 1 , Byrappa Kullaiah 1 , Debajani Basumatary 2 , Babu A. Manjasetty 1
Affiliation
|
Ruthenium complexes have been investigated for various biological applications by virtue of their radical scavenging, DNA binding, receptor binding, and cytotoxic abilities; especially the possible potential application of these complexes in photodynamic therapy (PDT). This study focuses on the synthesis, structural characterization and biological application (pertaining to its cytotoxicity and radical generation) of ruthenium complexed with salicylaldehyde fumaryl-dihydrazone (slfhH4), salicylaldehyde glutaryl-di-hydrazone (slfgH4) and 2,2′-bipyridine (bpy). During the synthesis, the anticipated complex was precipitated out but as serendipity, Ruthenium(II) tris (2,2′-bipyridyl) monochloride nonahydrate {[Ru(bpy)3]2+.Cl.9H2O} (RBMN) and Ruthenium(II) tris (2,2′-bipyridyl) monochloride septahydrate {[Ru(bpy)3]2+.Cl.7H2O}(RBMS) were crystallized from the filtrate. The crystal structure of complexes RBMN and RBMS were determined by a single-crystal X-ray diffraction methods and it showed that chlorine anion lies at the crystallographic axis and forms a halogen hydrogen-bonded organic framework (XHOF) to provide the stability. In comparison with similar structures in Cambridge Crystallographic Data Center (CCDC) revealed that the nature of the XHOF framework and the layered packing are conserved. The compounds showed excellent cytotoxic ability (against L6 cells) and the nitro blue tetrazolium (NBT) assay upon irradiation to light revealed its ability to produce reactive oxygen species (ROS). The presence of partially occupied water molecules in the layered organization within the crystal packing mimics the release of ROS resulting in cytotoxicity. The structural results together with the biological data make these complexes interesting candidates for potential photosensitizers for PDT applications.
中文翻译：
含2,2'-联吡啶配体的钌配合物的基于结构的生物学研究及其作为潜在光敏剂在光动力治疗中的应用
钌配合物凭借其自由基清除、DNA 结合、受体结合和细胞毒性能力，已被研究用于各种生物应用；特别是这些复合物在光动力疗法（PDT）中的潜在应用。本研究重点关注钌与水杨醛富马酰二腙 (slfhH 4 )、水杨醛戊二酰二腙 (slfgH 4 ) 和 2,2′- 络合的合成、结构表征和生物应用（与其细胞毒性和自由基生成有关）。联吡啶（bpy）。在合成过程中，预期的配合物沉淀出来，但作为偶然，钌(II)三(2,2'-联吡啶基)一氯化物九水合物{[Ru(bpy) 3 ] 2+ .Cl.9H 2 O } (RBMN)和从滤液中结晶出三(2,2'-联吡啶)一氯化钌(II)七水合物{[Ru(bpy) 3 ] 2+ ·Cl·7H 2 O}(RBMS)。通过单晶X射线衍射方法测定了配合物RBMN和RBMS的晶体结构，结果表明氯阴离子位于晶轴上并形成卤素氢键有机骨架（XHOF）以提供稳定性。与剑桥晶体学数据中心（CCDC）的类似结构相比，发现 XHOF 框架和分层堆积的性质是保守的。这些化合物表现出优异的细胞毒能力（针对 L6 细胞），并且光照射后的硝基蓝四唑 (NBT) 测定显示其产生活性氧 (ROS) 的能力。晶体堆积内的层状组织中部分占据的水分子的存在模拟了 ROS 的释放，从而导致细胞毒性。结构结果与生物数据一起使这些复合物成为 PDT 应用的潜在光敏剂的有趣候选者。
更新日期：2023-09-18
中文翻译：
含2,2'-联吡啶配体的钌配合物的基于结构的生物学研究及其作为潜在光敏剂在光动力治疗中的应用
钌配合物凭借其自由基清除、DNA 结合、受体结合和细胞毒性能力，已被研究用于各种生物应用；特别是这些复合物在光动力疗法（PDT）中的潜在应用。本研究重点关注钌与水杨醛富马酰二腙 (slfhH 4 )、水杨醛戊二酰二腙 (slfgH 4 ) 和 2,2′- 络合的合成、结构表征和生物应用（与其细胞毒性和自由基生成有关）。联吡啶（bpy）。在合成过程中，预期的配合物沉淀出来，但作为偶然，钌(II)三(2,2'-联吡啶基)一氯化物九水合物{[Ru(bpy) 3 ] 2+ .Cl.9H 2 O } (RBMN)和从滤液中结晶出三(2,2'-联吡啶)一氯化钌(II)七水合物{[Ru(bpy) 3 ] 2+ ·Cl·7H 2 O}(RBMS)。通过单晶X射线衍射方法测定了配合物RBMN和RBMS的晶体结构，结果表明氯阴离子位于晶轴上并形成卤素氢键有机骨架（XHOF）以提供稳定性。与剑桥晶体学数据中心（CCDC）的类似结构相比，发现 XHOF 框架和分层堆积的性质是保守的。这些化合物表现出优异的细胞毒能力（针对 L6 细胞），并且光照射后的硝基蓝四唑 (NBT) 测定显示其产生活性氧 (ROS) 的能力。晶体堆积内的层状组织中部分占据的水分子的存在模拟了 ROS 的释放，从而导致细胞毒性。结构结果与生物数据一起使这些复合物成为 PDT 应用的潜在光敏剂的有趣候选者。
京公网安备 11010802027423号