Catalyst-Free N-Formylation of Amines Using Formic Acid as a Sustainable C1 Source,ACS Sustainable Chemistry & Engineering

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Catalyst-Free N-Formylation of Amines Using Formic Acid as a Sustainable C1 Source
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2023-09-22 , DOI: 10.1021/acssuschemeng.3c04457
Hua Liang _{1,

2} , Tianxiang Zhao _{1,

2} , Jialong Ou _{1,

2} , Jia Liu ₃ , Xingbang Hu ₃

Affiliation

Formic acid, as an easily available C1 source, can be obtained through CO₂ hydrogenation or biomass smelting. For this perspective, N-formylation of amines with formic acid as the C1 synthon can be considered as indirect utilization of CO₂ or biomass, thus providing an alternative synthetic strategy. In this work, we present a sustainable protocol for the N-formylation of amines using formic acid as the carbonyl source under catalyst-free conditions. This procedure yields medium to excellent results for various formamides. Furthermore, we successfully extended this protocol to include the reduction coupling of formic acid, primary amines, and aldehydes, demonstrating broad substrate applicability.

中文翻译：

使用甲酸作为可持续 C1 源对胺进行无催化剂 N-甲酰化

甲酸作为一种容易获得的C1来源，可以通过CO ₂加氢或生物质熔炼获得。从这个角度来看，以甲酸作为C1合成子对胺进行N-甲酰化可以被认为是CO ₂或生物质的间接利用，从而提供了一种替代的合成策略。在这项工作中，我们提出了一种在无催化剂条件下使用甲酸作为羰基源对胺进行 N-甲酰化的可持续方案。该程序对各种甲酰胺产生中等至优异的结果。此外，我们成功地扩展了该方案，包括甲酸、伯胺和醛的还原偶联，证明了底物的广泛适用性。

更新日期：2023-09-22

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