Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect,ACS Applied Materials & Interfaces

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Liposomal Resveratrol Alleviates Platelet Storage Lesion via Antioxidation and the Physical Buffering Effect
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-09-20 , DOI: 10.1021/acsami.3c09935
Jiazhen Hou _{1,

2} , Wei Xiong _{3,

4} , Xinyue Shao ₂ , Li Long _{2,

4} , Ya Chang ₂ , Guihua Chen _{2,

4} , Li Wang _{5,

6} , Zhicheng Wang ₅ , Yongzhuo Huang _{1,

2,

3,

7}

Affiliation

Platelet transfusion is essential in the treatment of platelet-related diseases and the prevention of bleeding in patients with surgical procedures. Platelet transfusion efficacy and shelf life are limited mainly by the development of platelet storage lesion (PSL). Mitigating PSL is the key to prolonging the platelet shelf life and reducing wastage. Excess intracellular reactive oxygen species (ROS) are one of the main factors causing PSL. In this study, we explored a nanomedicine strategy to improve the quality and functions of platelets in storage. Resveratrol (Res), a natural plant product, is known for its antioxidative effect. However, medical applications of Res are limited due to its low water solubility and stability. Therefore, we used a resveratrol-loaded liposomal system (Res-Lipo) to better utilize the antioxidant effect of the drug. This study aimed to evaluate the effect of Res-Lipo on platelet oxidative stress and alleviation of PSL during the storage time. Res-Lipo scavenged intracellular ROS and inhibited platelet apoptosis and activation during storage. Res-Lipo not only maintained mitochondrial function but also improved platelet aggregation in response to adenosine 5′-diphosphate. These results revealed that Res-Lipo ameliorated PSL and prolonged the platelet survival time in vivo. The strategy provides a potential method for extending the platelet storage time and might be considered a potential and safe additive to alleviate PSL.

中文翻译：

脂质体白藜芦醇通过抗氧化和物理缓冲作用减轻血小板储存损伤

血小板输注对于治疗血小板相关疾病和预防外科手术患者出血至关重要。血小板输注功效和保质期主要受到血小板储存病变（PSL）的发展的限制。降低 PSL 是延长血小板保质期和减少浪费的关键。细胞内过多的活性氧（ROS）是引起PSL的主要因素之一。在这项研究中，我们探索了一种纳米医学策略来提高储存血小板的质量和功能。白藜芦醇（Res）是一种天然植物产品，以其抗氧化作用而闻名。然而，由于其水溶性和稳定性较低，Res的医学应用受到限制。因此，我们使用了负载白藜芦醇的脂质体系统（Res-Lipo）来更好地利用药物的抗氧化作用。本研究旨在评估Res-Lipo对储存期间血小板氧化应激和缓解PSL的影响。Res-Lipo 清除细胞内 ROS，并在储存过程中抑制血小板凋亡和活化。Res-Lipo 不仅维持了线粒体功能，还改善了 5'-二磷酸腺苷反应的血小板聚集。这些结果表明，Res-Lipo 改善了 PSL 并延长了血小板在体内的存活时间。该策略提供了一种延长血小板储存时间的潜在方法，并且可能被认为是减轻 PSL 的潜在且安全的添加剂。

更新日期：2023-09-20

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