Topics in Current Chemistry ( IF 7.1 ) Pub Date : 2023-09-22 , DOI: 10.1007/s41061-023-00437-6
Angel H Romero 1
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Herein, recent developments for Selectfluor-mediated C–H functionalization of N-heteroarenes are described. This type of C–H bond activation is an attractive and competitive alternative to traditional methodologies, allowing the functionalization of a variety of chemical functions. In addition, Selectfluor is a more sustainable and economically accessible oxidant compared with expensive/toxic metals or hazardous peroxides. For a practical understanding, the current review classified systematically the reported strategies in four subsections as follows: (1) carbon–carbon formation, (2) carbon–nitrogen bond formation, (3) carbon–chalcogen bond, and (4) carbon–halogen bond formation. Mechanistic aspects and reaction conditions are fully discussed to provide an understanding of the aspects that govern C–H functionalization in N-heteroarenes mediated by Selectfluor.
Graphical Abstract
中文翻译：
Selectflu 介导的 N-杂芳烃 C-H 键功能化
本文描述了Selectflor 介导的N-杂芳烃 C-H 官能化的最新进展。这种类型的 C-H 键激活是传统方法的一种有吸引力且有竞争力的替代方法，可以实现多种化学功能的功能化。此外，与昂贵/有毒的金属或危险的过氧化物相比，Selectflu 是一种更可持续、更经济的氧化剂。为了便于理解，本综述将报告的策略系统地分为以下四个小节：（1）碳-碳形成，（2）碳-氮键形成，（3）碳-硫族键，（4）碳-卤素键的形成。充分讨论了机理方面和反应条件，以提供对 Selectflor 介导的N-杂芳烃中控制 C-H 官能化的方面的理解。
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