生物医学抗菌水凝胶材料的最新进展,Journal of Materials Chemistry C

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生物医学抗菌水凝胶材料的最新进展
Journal of Materials Chemistry C ( IF 5.7 ) Pub Date : 2023-09-21 , DOI: 10.1039/d3tc02166a
Qian Wang ₁ , Xing Feng ₂ , Hong Xu ₃ , Guo Guo ₁ , Ying Li ₄ , Qilong Zhang ₃

Affiliation

抗菌水凝胶作为具有三维多孔网络结构的新型抗菌材料，通过适当选择凝胶组分、交联剂和功能分子或功能合成的水凝胶，具有固有或外源的抗菌活性、适当的机械性能以及局部使用的高生物相容性。基团可用于药物控制释放、刺激响应激活、协同抗菌治疗等。随着水凝胶功能化构建和性能调控技术的进步，抗菌水凝胶已广泛应用于生物医学相关领域，如药物递送、细胞封装、伤口愈合、骨修复、组织工程、医疗器械抗菌涂层、传感与检测等。健康监测。这里，我们从不同类型的抗菌水凝胶的成分、制备工艺、抗菌机制及其在生物医学领域的转化应用等方面介绍了不同类型的抗菌水凝胶。此外，讨论了抗菌水凝胶在医学领域应用的现状和瓶颈，有利于指明抗菌水凝胶在生物医学领域的未来研究方向。

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Recent progress of antibacterial hydrogel materials for biomedical applications

Antibacterial hydrogels, as novel antibacterial materials with three-dimensional porous network structures, have inherent or exogenous antibacterial activity, appropriate mechanical properties, and high biocompatibility for local use, and these hydrogels synthesized through appropriate selection of gel components, crosslinkers, and functional molecules or groups can be used for controlled release of drugs, stimulus-responsive activation, synergistic antibacterial therapy, and so forth. With the progress of the functionalized construction and the performance regulation technology of hydrogels, antibacterial hydrogels have been widely used in biomedical-related fields for drug delivery, cell encapsulation, wound healing, bone repair, tissue engineering, antibacterial coating of medical devices, sensing and health monitoring. Here, we introduce the different types of antibacterial hydrogels from their components, preparation processes, and antibacterial mechanisms to their translational applications in the biomedical field. In addition, the current situation and bottleneck for the application of antibacterial hydrogels in the medical field are discussed, which is beneficial for indicating the future research directions of antibacterial hydrogels in the biomedical field.

更新日期：2023-09-21

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