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Hemoperfusion Adsorbents for Removal of Common Toxins in Liver and Kidney Failure: Recent Progress, Challenges, and Prospects
Advanced Materials ( IF 27.4 ) Pub Date : 2023-08-11 , DOI: 10.1002/adma.202305152 Shuangquan Wu 1 , Pengpeng Yue 1 , Yongsheng Ma 1 , Yongkang Zou 1 , Wenjin Liang 1 , Qifa Ye 1
Advanced Materials ( IF 27.4 ) Pub Date : 2023-08-11 , DOI: 10.1002/adma.202305152 Shuangquan Wu 1 , Pengpeng Yue 1 , Yongsheng Ma 1 , Yongkang Zou 1 , Wenjin Liang 1 , Qifa Ye 1
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Liver and kidney failure can lead to extensive accumulation of toxic metabolites in the blood and tissues, such as bilirubin, blood ammonia, endotoxins, cytokines, creatinine, uric acid, and urea, which aggravate the progression of the disease. Hemoperfusion can effectively adsorb and remove toxins from the blood and treat liver and kidney failure. However, the adsorption efficiency and safety of traditional hemoperfusion adsorbents are not ideal. Thus, it is urgent to develop adsorbents with good blood compatibility, as well as high adsorption and strong selective capacities, to fulfill the clinical needs. In recent years, new hemoperfusion adsorbents with improved adsorption performance and good blood compatibility have been developed. This review classifies and summarizes the recent research progress in hemoperfusion adsorbents for common blood toxins (bilirubin, blood ammonia, endotoxins, cytokines, creatinine, uric acid, and urea) produced by liver and kidney failure. The composition and structure of various toxin adsorbents, toxin adsorption performance, biocompatibility, blood safety, and the adsorption mechanisms of toxins are discussed. Based on a summary of recent studies, feasible strategies have been explored for designing and preparing hemoperfusion adsorbents to fulfill future development requirements. The trends and clinical application prospects of various toxin adsorbents are also discussed.
中文翻译：
血液灌流吸附剂去除肝肾衰竭常见毒素：最新进展、挑战和前景
肝肾衰竭可导致血液和组织中有毒代谢物大量蓄积，如胆红素、血氨、内毒素、细胞因子、肌酐、尿酸、尿素等，加重病情进展。血液灌流可以有效吸附和清除血液中的毒素，治疗肝肾衰竭。然而传统血液灌流吸附剂的吸附效率和安全性并不理想。因此，迫切需要开发具有良好的血液相容性、高吸附性和强选择性的吸附剂来满足临床需求。近年来，人们开发了新型血液灌流吸附剂，具有改进的吸附性能和良好的血液相容性。本文对肝肾功能衰竭产生的常见血液毒素（胆红素、血氨、内毒素、细胞因子、肌酐、尿酸、尿素）血液灌流吸附剂的最新研究进展进行了分类和总结。讨论了各种毒素吸附剂的组成和结构、毒素吸附性能、生物相容性、血液安全性以及毒素的吸附机制。基于最近研究的总结，探索了设计和制备血液灌流吸附剂以满足未来发展要求的可行策略。并对各种毒素吸附剂的发展趋势和临床应用前景进行了讨论。
更新日期：2023-08-11
中文翻译：
血液灌流吸附剂去除肝肾衰竭常见毒素：最新进展、挑战和前景
肝肾衰竭可导致血液和组织中有毒代谢物大量蓄积，如胆红素、血氨、内毒素、细胞因子、肌酐、尿酸、尿素等，加重病情进展。血液灌流可以有效吸附和清除血液中的毒素，治疗肝肾衰竭。然而传统血液灌流吸附剂的吸附效率和安全性并不理想。因此，迫切需要开发具有良好的血液相容性、高吸附性和强选择性的吸附剂来满足临床需求。近年来，人们开发了新型血液灌流吸附剂，具有改进的吸附性能和良好的血液相容性。本文对肝肾功能衰竭产生的常见血液毒素（胆红素、血氨、内毒素、细胞因子、肌酐、尿酸、尿素）血液灌流吸附剂的最新研究进展进行了分类和总结。讨论了各种毒素吸附剂的组成和结构、毒素吸附性能、生物相容性、血液安全性以及毒素的吸附机制。基于最近研究的总结，探索了设计和制备血液灌流吸附剂以满足未来发展要求的可行策略。并对各种毒素吸附剂的发展趋势和临床应用前景进行了讨论。
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