The divergent reductive cross-coupling with an ambident electrophile is rare. Previously, we demonstrated a nickel-catalyzed reductive 2-pyridination of aryl iodides with difluoromethyl 2-pyridyl sulfone (2-PySO₂CF₂H) via selective C(sp²)–S bond cleavage of the sulfone by using a phosphine ligand. In this communication, we report a novel nickel-catalyzed reductive coupling of aryl iodides and 2-PySO₂CF₂H reagent, which constitutes a new method for aromatic difluoromethylation. The use of a tridentate terpyridine ligand is pivotal for the selective C(sp³)–S bond cleavage of the sulfone. This method employs readily available nickel catalyst and 2-PySO₂CF₂H as the difluoromethylation reagent, providing a facile access to difluoromethylarenes under mild reaction conditions without pre-generation of arylmetal reagents.

与环境亲电子试剂的发散还原交叉偶联是罕见的。此前，我们通过使用膦配体选择性裂解砜的 C(sp ² ) –S 键，演示了镍催化的芳基碘化物与二氟甲基 2-吡啶基砜 (2-PySO 2 _CF 2 _H )的还原 2-吡啶化反应。_{在本次通讯中，我们报道了一种新型的镍催化芳基碘化物与2-PySO 2} CF ₂ H试剂的还原偶联，构成了芳香族二氟甲基化的新方法。三齿三联吡啶配体的使用对于砜的选择性 C(sp ³ )-S 键断裂至关重要。该方法采用现成的镍催化剂和 2-PySO₂ CF ₂ H作为二氟甲基化试剂，可以在温和的反应条件下轻松获得二氟甲基芳烃，而无需预先生成芳基金属试剂。