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AuPt Nanoparticle-Based Injectable Hydrogel as Cascade Nanozyme for Accelerating Bacteria-Infected Wound Healing
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-09-19 , DOI: 10.1021/acsanm.3c02693 Huiyuan Bai 1 , Zihan Ding 1 , Jiaxi Qian 1 , Maorong Jiang 1 , Dengbing Yao 1
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2023-09-19 , DOI: 10.1021/acsanm.3c02693 Huiyuan Bai 1 , Zihan Ding 1 , Jiaxi Qian 1 , Maorong Jiang 1 , Dengbing Yao 1
Affiliation
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Bacterial infections have been the main obstacle of wound healing in clinic. Conventional antibiotics have been widely used for bacterial infections therapy. However, the misuse and long-term use of antibiotics could induce drug resistance, resulting in the reduced antibacterial effect. Recently, the nanozyme-based combination therapy mode has emerged as a promising strategy to achieve enhanced antibacterial effect with different antimicrobial mechanisms. Inspired by this, a gold/platinum nanoparticle-based injectable hydrogel with nanozyme and photothermal properties was developed for accelerating bacteria-infected wound healing. In detail, gold/platinum nanoparticles (AuPt NPs) were prepared by reducing metal precursors in the presence of ascorbic acid. Then, AuPt NPs and GOx were incubated with thiol-terminated four-arm polyethylene glycol to form injectable AuPt/GOx gel. The AuPt/GOx gel possessed a cascade catalytic activity: GOx converted glucose into gluconic acid and hydrogen peroxide (H2O2) and subsequently promote peroxidase-like reaction of AuPt NPs to transfer H2O2 into a more toxic hydroxyl free radical for destroying bacteria. More than that, AuPt/GOx gel displayed a good photothermal effect. The wound healing rate in AuPt/GOx gel + glucose + NIR group was the fastest, which is attributed to the synergistic effect of nanozyme activity and photothermal effect. This work provides a safe and robust strategy for bacterial infection therapy.
中文翻译：
基于 AuPt 纳米颗粒的可注射水凝胶作为级联纳米酶，可加速细菌感染的伤口愈合
细菌感染一直是临床上伤口愈合的主要障碍。常规抗生素已广泛用于细菌感染治疗。但滥用和长期使用抗生素会引起耐药性，导致抗菌效果降低。最近，基于纳米酶的联合治疗模式已成为一种有前途的策略，可以通过不同的抗菌机制实现增强的抗菌效果。受此启发，开发了一种具有纳米酶和光热特性的基于金/铂纳米粒子的可注射水凝胶，用于加速细菌感染的伤口愈合。具体来说，金/铂纳米颗粒（AuPt NP）是通过在抗坏血酸存在下还原金属前体来制备的。然后，将 AuPt NPs 和 GOx 与硫醇封端的四臂聚乙二醇一起孵育，形成可注射的 AuPt/GOx 凝胶。AuPt/GOx凝胶具有级联催化活性：GOx将葡萄糖转化为葡萄糖酸和过氧化氢(H 2 O 2 )，随后促进AuPt NPs的过氧化物酶样反应，将H 2 O 2转化为毒性更强的羟基自由基消灭细菌。更重要的是，AuPt/GOx 凝胶表现出良好的光热效应。AuPt/GOx凝胶+葡萄糖+NIR组的伤口愈合速度最快，这归因于纳米酶活性和光热效应的协同作用。这项工作为细菌感染治疗提供了安全可靠的策略。
更新日期：2023-09-19
中文翻译：
基于 AuPt 纳米颗粒的可注射水凝胶作为级联纳米酶，可加速细菌感染的伤口愈合
细菌感染一直是临床上伤口愈合的主要障碍。常规抗生素已广泛用于细菌感染治疗。但滥用和长期使用抗生素会引起耐药性，导致抗菌效果降低。最近，基于纳米酶的联合治疗模式已成为一种有前途的策略，可以通过不同的抗菌机制实现增强的抗菌效果。受此启发，开发了一种具有纳米酶和光热特性的基于金/铂纳米粒子的可注射水凝胶，用于加速细菌感染的伤口愈合。具体来说，金/铂纳米颗粒（AuPt NP）是通过在抗坏血酸存在下还原金属前体来制备的。然后，将 AuPt NPs 和 GOx 与硫醇封端的四臂聚乙二醇一起孵育，形成可注射的 AuPt/GOx 凝胶。AuPt/GOx凝胶具有级联催化活性：GOx将葡萄糖转化为葡萄糖酸和过氧化氢(H 2 O 2 )，随后促进AuPt NPs的过氧化物酶样反应，将H 2 O 2转化为毒性更强的羟基自由基消灭细菌。更重要的是，AuPt/GOx 凝胶表现出良好的光热效应。AuPt/GOx凝胶+葡萄糖+NIR组的伤口愈合速度最快，这归因于纳米酶活性和光热效应的协同作用。这项工作为细菌感染治疗提供了安全可靠的策略。
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