Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease.

中文翻译：

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弥漫性胸膜间皮瘤的分子发病机制、诊断和治疗进展


弥漫性胸膜间皮瘤 （DPM） 是一种高度侵袭性的恶性肿瘤，起源于胸膜表面的间皮细胞。虽然 DPM 是一种公认的与石棉暴露有关的疾病，但最近的进展扩大了我们对分子发病机制的理解并改变了我们的临床实践。本综述探讨了 DPM 的当前概念和新兴趋势，包括风险因素、病理生物学、组织学亚型和治疗管理，重点是针对这种复杂疾病的多学科方法。