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Antifouling and Injectable Granular Hydrogel for the Prevention of Postoperative Intrauterine Adhesion
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-09-18 , DOI: 10.1021/acsami.3c07846 Weiting Xia , Qilin Wang 1 , Ming Liu , Shaoping Lu 1 , Hui Yu 1 , Haiyan Yin 1 , Min You 1 , Qiang Chen 1 , Bujun Wang 2 , Feng Lin
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2023-09-18 , DOI: 10.1021/acsami.3c07846 Weiting Xia , Qilin Wang 1 , Ming Liu , Shaoping Lu 1 , Hui Yu 1 , Haiyan Yin 1 , Min You 1 , Qiang Chen 1 , Bujun Wang 2 , Feng Lin
Affiliation
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Postoperative intrauterine adhesion (IUA), caused by endometrial basal layer injury, is one of the main causes of female infertility. The excessive deposition of fibrin as well as fibroblast is considered the root cause of IUA. However, few clinical strategies are effective in preventing extracellular matrix (ECM) deposition at endometrial wounds that include protein and cell deposits. Herein, the injectable granular poly(N-(2-hydroxyethyl) acrylamide) (PHEAA) hydrogel (granular PHEAA gel), which presents excellent antifouling properties and remarkably prevents protein and cell adhesions, is used to prevent postoperative IUA. The granular PHEAA gel with a jammed network structure exhibits outstanding injectability and superior stability. Compared with the IUA group, the granular PHEAA gel can promote regeneration of the endometrium while reducing the area of endometrial fibrosis. Immunohistochemical staining experiments indicate that the granular PHEAA gel can improve the proliferation of the endometrium, promote vascularization, and enhance anti-inflammatory effect in IUA rats. And the granular PHEAA gel can effectively slow down the fibrosis of uterine tissue. Importantly, the number of embryos is significantly increased after injecting granular PHEAA gel, inferring that there is an obvious reproductive function recovery of injured endometrium.
中文翻译：
防污可注射颗粒水凝胶预防术后宫腔粘连
术后宫腔粘连（IUA）是由子宫内膜基底层损伤引起的，是女性不孕的主要原因之一。纤维蛋白和成纤维细胞的过度沉积被认为是IUA的根本原因。然而，很少有临床策略能够有效预防子宫内膜伤口处的细胞外基质（ECM）沉积，其中包括蛋白质和细胞沉积物。在此，可注射颗粒状聚（N-（2-羟乙基）丙烯酰胺）（PHEAA）水凝胶（颗粒状PHEAA凝胶）具有优异的防污性能，可显着防止蛋白质和细胞粘附，用于预防术后IUA。具有堵塞网络结构的粒状PHEAA凝胶具有出色的注射性和优异的稳定性。与IUA组相比，颗粒状PHEAA凝胶可以促进子宫内膜再生，同时减少子宫内膜纤维化面积。免疫组化染色实验表明，颗粒状PHEAA凝胶可以改善IUA大鼠子宫内膜增殖，促进血管化，增强抗炎作用。而颗粒状的PHEAA凝胶可以有效减缓子宫组织的纤维化。重要的是，注射颗粒状PHEAA凝胶后胚胎数量显着增加，推断受损子宫内膜的生殖功能有明显恢复。
更新日期：2023-09-18
中文翻译：
防污可注射颗粒水凝胶预防术后宫腔粘连
术后宫腔粘连（IUA）是由子宫内膜基底层损伤引起的，是女性不孕的主要原因之一。纤维蛋白和成纤维细胞的过度沉积被认为是IUA的根本原因。然而，很少有临床策略能够有效预防子宫内膜伤口处的细胞外基质（ECM）沉积，其中包括蛋白质和细胞沉积物。在此，可注射颗粒状聚（N-（2-羟乙基）丙烯酰胺）（PHEAA）水凝胶（颗粒状PHEAA凝胶）具有优异的防污性能，可显着防止蛋白质和细胞粘附，用于预防术后IUA。具有堵塞网络结构的粒状PHEAA凝胶具有出色的注射性和优异的稳定性。与IUA组相比，颗粒状PHEAA凝胶可以促进子宫内膜再生，同时减少子宫内膜纤维化面积。免疫组化染色实验表明，颗粒状PHEAA凝胶可以改善IUA大鼠子宫内膜增殖，促进血管化，增强抗炎作用。而颗粒状的PHEAA凝胶可以有效减缓子宫组织的纤维化。重要的是，注射颗粒状PHEAA凝胶后胚胎数量显着增加，推断受损子宫内膜的生殖功能有明显恢复。
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