Deciphering m6A dynamics at a single-base level during planarian anterior-posterior axis specification,Computational and Structural Biotechnology Journal

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Deciphering m6A dynamics at a single-base level during planarian anterior-posterior axis specification
Computational and Structural Biotechnology Journal ( IF 4.4 ) Pub Date : 2023-09-18 , DOI: 10.1016/j.csbj.2023.09.018
Liqian Chen ₁ , Hui Zhen ₁ , Zixin Chen ₁ , Mujie Huang ₁ , Daniel W Mak ₂ , Wei Jin ₁ , Yuxiu Zou ₁ , Mingjie Chen ₃ , Mingyue Zheng ₁ , Qingqiang Xie ₁ , Zhongjun Zhou ₂ , Guoxiang Jin ₁

Affiliation

The establishment of the anterior-posterior (A-P) axis is a crucial step during tissue repair and regeneration. Despite the association reported recently of N6-methyladenosine (m6A) with regeneration, the mechanism underlying the regulation of m6A in A-P axis specification during regeneration remains unknown. Herein, we deciphered the m6A landscape at a single-base resolution at multiple time points during A-P axis regeneration and constructed the de novo transcriptome assembly of the Dugesia japonica planarian.

中文翻译：

在涡虫前后轴规范期间在单碱基水平上破译 m6A 动力学

前后（A-P）轴的建立是组织修复和再生过程中的关键步骤。尽管最近报道了 N6-甲基腺苷（m6A）与再生的关联，但在再生过程中 m6A 在 AP 轴规格中的调节机制仍然未知。在此，我们在 A-P 轴再生过程中的多个时间点以单碱基分辨率破译了 m6A 景观，并构建了 Dugesia japonica 涡虫的从头转录组组装。

更新日期：2023-09-18

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