<br>免晒美黑产品中外用二羟基丙酮的特性和安全性：综述,Photodermatology, Photoimmunology & Photomedicine

当前位置： X-MOL 学术 › Photodermatol. Photoimmunol. Photomed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

免晒美黑产品中外用二羟基丙酮的特性和安全性：综述
Photodermatology, Photoimmunology & Photomedicine ( IF 2.5 ) Pub Date : 2023-09-12 , DOI: 10.1111/phpp.12913
Shayan Owji ₁ , Fayven Teklehaimanot ₂ , Jalal Maghfour ₃ , Henry W Lim ₃

Affiliation

随着人们对晒黑外观的渴望不断增加，同时人们越来越担心太阳紫外线辐射的有害影响，免晒美黑产品越来越受欢迎。二羟基丙酮 (DHA) 是一种简单碳水化合物，几乎普遍存在于免晒美黑产品中，可赋予皮肤色彩。美国食品和药物管理局 (FDA) 将免晒美黑产品作为化妆品进行监管，允许 DHA 外用，但应避免摄入、吸入或与粘膜表面接触。鉴于 DHA 的广泛使用和对其安全性的评论很少，我们旨在回顾有关 DHA 的局部特性和安全性的文献。现有数据表明，DHA 仅具有极小的光防护特性，甚至没有可观察到的光防护特性。体外研究表明，虽然 DHA 浓度远高于免晒美黑产品中的浓度才能诱导显着的细胞毒性，但即使是低毫摩尔、非致命浓度也可以在细胞和分子水平上改变角质形成细胞、气管支气管细胞和其他细胞类型的功能。也有因 DHA 暴露引发刺激性和过敏性接触性皮炎的报道。虽然尚未观察到对人类的其他副作用，但有必要对 DHA 对人类的安全性和毒性进行更多研究，重点关注消费者通常遇到的 DHA 暴露浓度和频率。

"点击查看英文标题和摘要"

Properties and safety of topical dihydroxyacetone in sunless tanning products: A review

Sunless tanning products have risen in popularity as the desire for a tanned appearance continues alongside growing concerns about the deleterious effects of ultraviolet radiation exposure from the sun. Dihydroxyacetone (DHA) is a simple carbohydrate found nearly universally in sunless tanning products that serves to impart color to the skin. The Food and Drug Administration (FDA), which regulates sunless tanning products as cosmetics, allows DHA for external use while maintaining that its ingestion, inhalation, or contact with mucosal surfaces should be avoided. Given its widespread use and a paucity of reviews on its safety, we aim to review the literature on the topical properties and safety profile of DHA. Available data indicate that DHA possesses only minimal to no observable photoprotective properties. In vitro studies suggest that, while DHA concentrations much higher than those in sunless tanning products are needed to induce significant cytotoxicity, even low millimolar, nonlethal concentrations can alter the function of keratinocytes, tracheobronchial cells, and other cell types on a cellular and molecular level. Instances of irritant and allergic contact dermatitis triggered by DHA exposures have also been reported. While no other side effects in humans have been observed, additional studies on the safety and toxicity of DHA in humans are warranted, with a focus on concentrations and frequencies of DHA exposure typically encountered by consumers.

更新日期：2023-09-12

点击分享查看原文

点击收藏

公开下载

阅读更多本刊新发论文