Objectives

Periodontitis is a chronic infectious disease, which leads to inflammatory destruction of periodontal supporting tissues. Interleukin 14 (IL-14), Interleukin 16 (IL-16) and serum amyloid A (SAA) have been demonstrated to be abnormally expressed in inflammatory diseases. Therefore, this study was performed to analyzed the expression and potential clinical values of IL-14, 1L-16 and SAA in periodontitis.

Materials and methods

A total of 100 periodontitis patients and 100 healthy volunteers were recruited and the saliva and serum samples were collected. Then the C-reactive protein (CRP), procalcitonin (PCT), IL-14, 1L-16 and SAA levels in the saliva and serum of periodontitis patients were measured by Elisa kits. Besides, the significance of CRP, PCT, IL-14, 1L-16 and SAA in periodontitis patients were analyzed by receiver operating characteristic (ROC) analysis.

Results

The results showed that CRP, PCT, IL-14, 1L-16 and SAA levels were significantly increased in the the saliva and serum of the periodontitis patients. Additionally, the area under the curve (AUC) of saliva CRP, PCT, IL-14, 1L-16 and SAA for the diagnosis of periodontitis were 0.9035, 0.9435, 0.9508, 0.9500 and 0.9467, respectively. The AUC of serum CRP, PCT, IL-14, 1L-16 and SAA for the diagnosis of periodontitis were 0.9035, 0.9435, 0.9508, 0.9500 and 0.9467, respectively. What’s more, the diagnostic value of IL-14, 1L-16 and SAA were enhanced when combining with CRP and PCT.

Conclusion and clinical relevance

This study demonstrated that IL-14, IL-16 and SAA expressions were upregulated in periodontitis patients and exhibited a significant significance for periodontitis diagnosis.

中文翻译：

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IL-14、1L-16、SAA对牙周炎的临床诊断价值

目标

牙周炎是一种慢性感染性疾病，会导致牙周支持组织发生炎症性破坏。白细胞介素 14 (IL-14)、白细胞介素 16 (IL-16) 和血清淀粉样蛋白 A (SAA) 已被证明在炎症性疾病中异常表达。因此，本研究旨在分析IL-14、1L-16和SAA在牙周炎中的表达及其潜在临床价值。

材料和方法

共招募100名牙周炎患者和100名健康志愿者，采集唾液和血清样本。采用Elisa试剂盒测定牙周炎患者唾液和血清中C反应蛋白（CRP）、降钙素原（PCT）、IL-14、1L-16、SAA的含量。此外，通过受试者工作特征（ROC）分析，分析CRP、PCT、IL-14、1L-16和SAA在牙周炎患者中的意义。

结果

结果显示，牙周炎患者唾液和血清中CRP、PCT、IL-14、1L-16和SAA水平显着升高。此外，唾液CRP、PCT、IL-14、1L-16和SAA诊断牙周炎的曲线下面积（AUC）分别为0.9035、0.9435、0.9508、0.9500和0.9467。血清CRP、PCT、IL-14、1L-16和SAA诊断牙周炎的AUC分别为0.9035、0.9435、0.9508、0.9500和0.9467。更重要的是，IL-14、1L-16和SAA与CRP和PCT联合诊断价值增强。

结论和临床相关性

本研究表明牙周炎患者中IL-14、IL-16和SAA的表达上调，对牙周炎的诊断具有重要意义。