COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1 receptor. Recent lines of experimental evidence have indicated that COR659 potently and effectively reduced operant self-administration of and reinstatement of seeking behaviour for a chocolate-flavoured beverage. The present study was designed to assess whether the ability of COR659 to diminish these addictive-like, food-motivated behaviours extended to a rat model of overeating palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-hour chow-feeding session was followed by a 1-hour feeding session with highly palatable, calorie-rich Danish butter cookies. Even though satiated, rats overconsumed cookies. COR659 (0, 2.5, 5, and 10 mg/kg, i.p.) was administered before the start of the cookie-feeding session. Treatment with all 3 doses of COR659 produced a substantial decrease in intake of cookies and calories from cookies. These results extend the anorectic profile of COR659 to overconsumption of a highly palatable food and intake of large amounts of unnecessary calories.

中文翻译：

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COR659 对暴饮暴食大鼠模型的厌食作用。

COR659 是一种新化合物，其作用通过双重机制发挥作用：GABAB 受体的正变构调节；对大麻素 CB1 受体的拮抗或反向激动。最近的一系列实验证据表明，COR659 有力且有效地减少了对巧克力味饮料的操作性自我管理和恢复寻找行为。本研究旨在评估 COR659 减少这些成瘾性、食物诱发行为的能力是否可以扩展到暴饮暴食可口食物的大鼠模型。为此，使大鼠习惯于每天吃标准大鼠饲料3小时；每 4 天，在 3 小时的食物喂养后，进行 1 小时的美味、热量丰富的丹麦黄油饼干喂养。尽管吃饱了，老鼠还是过量食用了饼干。在饼干喂养开始前给予 COR659（0、2.5、5 和 10 mg/kg，腹膜内注射）。使用所有 3 剂 COR659 进行治疗后，饼干的摄入量和饼干中的热量均大幅减少。这些结果将 COR659 的厌食特性扩展到过度食用高度适口的食物和摄入大量不必要的卡路里。