虾青素对电离辐射引起的 DNA 损伤的体内保护功效,Chemical Biology & Drug Design

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虾青素对电离辐射引起的 DNA 损伤的体内保护功效
Chemical Biology & Drug Design ( IF 3.2 ) Pub Date : 2023-08-06 , DOI: 10.1111/cbdd.14321
Dilek Aşcı Çelik ₁ , Vehbi Atahan Toğay ₁

Affiliation

虾青素是一种类胡萝卜素色素，被认为可以有效修复 DNA 损伤。我们的研究使用彗星试验评估了虾青素对接受全身放射治疗的大鼠 DNA 损伤的影响。32只雄性大鼠随机分为四组（对照组、电离辐射组、虾青素组、辐射+虾青素组）。辐射组和辐射+虾青素组暴露于剂量为8戈瑞（0.62戈瑞/分钟）的X射线。从照射开始7天以4mg/kg强饲法施用虾青素。选择 %TailDNA 参数作为 DNA 损伤的指标，并使用单向方差分析对结果进行比较。对照组中％TailDNA为3.24±3.12，虾青素组中为2.85±2.73，辐射组中为4.11±7.90，辐射+虾青素组中为3.59±4.05。p < .001)。与辐射组相比，辐射+虾青素组的 DNA 损伤减少 ( p < .05)。虽然这种下降并没有减少对对照组水平的损害，但意义重大。在我们的研究中，施用虾青素可减少辐射引起的 DNA 损伤，这支持了虾青素是一种有前景的抗/减少 DNA 损伤剂的假设。

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In vivo protective efficacy of astaxanthin against ionizing radiation-induced DNA damage

Astaxanthin, a carotenoid pigment, is believed to be effective in the repair of DNA damage. Our study evaluates the effect of astaxanthin on DNA damage in rats exposed to whole-body radiotherapy using the comet assay. Thirty-two male rats were randomly divided into four groups (control, ionizing radiation, astaxanthin, and radiation+astaxanthin). The radiation and radiation+astaxanthin groups were exposed to X-rays at a dose of 8 gray (0.62 gray/min). Astaxanthin was administered at 4 mg/kg by gavage for 7 days starting from irradiation. The %TailDNA parameter was chosen as an indicator of DNA damage and the results were compared using one-way ANOVA. %TailDNA was 3.24 ± 3.12 in the control group, 2.85 ± 2.73 in the astaxanthin group, 4.11 ± 7.90 in the radiation group, and 3.59 ± 4.05 in the radiation+astaxanthin group. There was a significant increase in DNA damage in the radiation group, compared with the control and astaxanthin groups (p < .001). DNA damage was reduced in the radiation+astaxanthin group compared with the radiation group (p < .05). Although this decrease did not reduce damage to the level of the control group, it was significant. The decrease in radiation-induced DNA damage by astaxanthin administration in our study supports the hypothesis that astaxanthin is a promising agent for against/reducing DNA damage.

更新日期：2023-08-06

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