In this work, we explore how adding a catalytic amount of an NC-type ligand improves ketone-directed ortho C−H arylation, whereas a full equivalent shuts down the transformation. Increased catalytic activity stems from the formation of a cyclometallated complex containing the NC-type ligand to provide an intermediate which accelerates the ortho-arylation of the ketone substrate.

中文翻译：

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2-(邻甲苯基)吡啶作为配体提高酮定向邻位芳基化的效率

在这项工作中，我们探索了如何添加催化量的 NC 型配体来改善酮定向的邻位C−H 芳基化，而完全等价的配体会阻止该转化。催化活性的增加源于含有NC型配体的环金属化络合物的形成，以提供加速酮底物邻位芳基化的中间体。