Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long-Term Osteointegration in Irregular Craniofacial Reconstruction,Advanced Functional Materials

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Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long-Term Osteointegration in Irregular Craniofacial Reconstruction
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-09-12 , DOI: 10.1002/adfm.202304308
Quanying Liu _{1,

2} , Lei Tong _{1,

2} , Manyu Chen _{1,

2} , Peilei Wang _{1,

2} , En Luo ₃ , Jie Liang _{1,

2} , Xingdong Zhang _{1,

2} , Yujiang Fan _{1,

2} , Yong Sun _{1,

2}

Affiliation

The desired clinical bone prostheses should achieve satisfactory interface integration and osteoinduction, as well as good surgical convenience. Here, a highly malleable 3D printed prosthesis with compressive strength at 13 MPa is constructed by dopamine, polyvinyl alcohol, and micro-sized hydroxyapatite (86 wt%) as composite bioinks, which is endowed with good plasticity and can quickly match irregular defects by easily trimming. Spatially decorated collagen and hyaluronan greatly enriched the hierarchical microstructure and biological activity of malleable prosthesis. This prosthesis accelerates the proliferation and osteogenic differentiation of stem cells, regulates M2 polarization of macrophage, and promotes endogenous stem cell recruitment and early angiogenesis. Meanwhile, it significantly reinforces biomineralized deposition and vascularization, reaches full coverage of new bone in the rabbit cranial defect after 15 weeks (Φ = 10 mm), and achieves well osseointegration capacity with interfacial binding strength at 71.2% of the natural skull. This osteoinductive prosthesis provides a new design idea for bone filling.

中文翻译：

具有分层微观结构的高度可塑性个性化假体可促进不规则颅面重建的长期骨整合

临床理想的骨假体应实现令人满意的界面整合和骨诱导，以及良好的手术便利性。这里，由多巴胺、聚乙烯醇和微米级羟基磷灰石（86 wt%）作为复合生物墨水构建了一种具有13 MPa抗压强度的高延展性3D打印假体，该假体具有良好的可塑性，可以快速匹配不规则的缺陷。修剪。空间修饰的胶原蛋白和透明质酸极大地丰富了可塑假体的分层微观结构和生物活性。该假体加速干细胞的增殖和成骨分化，调节巨噬细胞的M2极化，促进内源性干细胞募集和早期血管生成。同时，它显着增强了生物矿化沉积和血管化，15周后（Φ = 10 mm）达到了兔颅骨缺损中新骨的完全覆盖，并实现了良好的骨整合能力，界面结合强度为天然颅骨的71.2%。这种骨诱导假体为骨填充提供了新的设计思路。

更新日期：2023-09-12

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