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An Aqueous Three-Component Reaction of Cyclopropanols, DABCO ⋅ (SO2)2 and Diaryliodonium salts
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2023-09-13 , DOI: 10.1002/adsc.202300839 Yanjie Qiu 1 , Jiating Yao 1 , Hongguang Xia 2 , Chumeng Zhu 1 , Shengqing Ye 1 , Jie Wu 1 , Qi Chen 3
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2023-09-13 , DOI: 10.1002/adsc.202300839 Yanjie Qiu 1 , Jiating Yao 1 , Hongguang Xia 2 , Chumeng Zhu 1 , Shengqing Ye 1 , Jie Wu 1 , Qi Chen 3
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An additive- and external oxidant-free reaction of cyclopropanols, DABCO ⋅ (SO2)2 and diaryliodonium salts in aqueous phase is described. This reaction proceeds under mild reaction conditions, affording bioactive aryl substituted γ-keto sulfones in 36%-90% yields with good functional group tolerance. This reaction proceeds through a γ-keto sulfinate intermediate, which undergoes a nucleophilic reaction with diaryliodonium salts, giving rise to corresponding aryl substituted γ-keto sulfones.
中文翻译：
环丙醇、DABCO·(SO2)2 和二芳基碘鎓盐的水相三组分反应
描述了环丙醇、DABCO·(SO 2 ) 2和二芳基碘鎓盐在水相中的无添加剂和无外部氧化剂的反应。该反应在温和的反应条件下进行，以36%-90%的产率提供具有良好官能团耐受性的生物活性芳基取代的γ-酮砜。该反应通过γ-酮亚磺酸盐中间体进行，该中间体与二芳基碘鎓盐发生亲核反应，产生相应的芳基取代的γ-酮砜。
更新日期：2023-09-13
中文翻译：
环丙醇、DABCO·(SO2)2 和二芳基碘鎓盐的水相三组分反应
描述了环丙醇、DABCO·(SO 2 ) 2和二芳基碘鎓盐在水相中的无添加剂和无外部氧化剂的反应。该反应在温和的反应条件下进行，以36%-90%的产率提供具有良好官能团耐受性的生物活性芳基取代的γ-酮砜。该反应通过γ-酮亚磺酸盐中间体进行，该中间体与二芳基碘鎓盐发生亲核反应，产生相应的芳基取代的γ-酮砜。
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