Instant Protection Spray for Anti-Infection and Accelerated Healing of Empyrosis,Advanced Materials

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Instant Protection Spray for Anti-Infection and Accelerated Healing of Empyrosis
Advanced Materials ( IF 27.4 ) Pub Date : 2023-09-13 , DOI: 10.1002/adma.202306589
Wei Guan _{1,

2,

3} , Caixin Gong ₂ , Shuilin Wu _{1,

2,

3} , Zhenduo Cui ₁ , Yufeng Zheng ₃ , Zhaoyang Li ₁ , Shengli Zhu ₁ , Xiangmei Liu _{2,

4}

Affiliation

Distinct from common injuries, deep burns often require a chronic recovery cycle for healing and long-term antibiotic treatment to prevent infection. The rise of drug-resistant bacteria has caused antibiotics to no longer be perfect, and continuous drug use can easily lead to repeated infection and even death. Inspired by wild animals that chew plants to prevent wound infection, probiotic extracts with a structure similar to the tailspike of phage are obtained from Lactobacillus casei and combined with different flavones to design a series of nonantibiotic bactericides. These novel antibacterial agents are combined with a rapid gelation spray with a novel cross-angle layout to form an instant protection spray (IPS) and provide a physical and anti-infectious barrier for burns within 30 s. This IPS is able to sterilize 100.00% and 96.14% of multidrug-resistant Staphylococcus aureus (MRSA) in vitro and in vivo, respectively. In addition, it is found to effectively reduce inflammation in MRSA-infected burns in rats and to promote tissue healing.

中文翻译：

用于抗感染和加速烧伤愈合的即时保护喷雾

与常见损伤不同，深度烧伤通常需要长期的恢复周期才能愈合，并需要长期抗生素治疗以预防感染。耐药菌的兴起使得抗生素不再完善，持续用药很容易导致反复感染甚至死亡。受到野生动物咀嚼植物来预防伤口感染的启发，从干酪乳杆菌中获得结构类似于噬菌体尾刺的益生菌提取物，并与不同的黄酮组合，设计出一系列非抗生素杀菌剂。这些新型抗菌剂与具有新颖交叉角布局的快速凝胶喷雾剂相结合，形成即时保护喷雾剂（IPS），并在30秒内为烧伤提供物理和抗感染屏障。该IPS能够在体外和体内分别对多重耐药金黄色葡萄球菌（MRSA）杀菌100.00%和96.14%。此外，它还被发现可以有效减少大鼠 MRSA 感染烧伤的炎症并促进组织愈合。

更新日期：2023-09-13

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