当前位置：
X-MOL 学术
›
Adv. Funct. Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Cellular Mechanisms Driving the Distinct Behavior of Trichocyte Keratins in Wound Healing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-09-13 , DOI: 10.1002/adfm.202307634 Wenfeng Li 1 , Rui Qing 2 , Haojie Zhang 1 , Ziwei Wang 1 , Yuhan Yuan 1 , Lili Wang 1 , Jia Deng 3 , Bochu Wang 1 , Shilei Hao 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-09-13 , DOI: 10.1002/adfm.202307634 Wenfeng Li 1 , Rui Qing 2 , Haojie Zhang 1 , Ziwei Wang 1 , Yuhan Yuan 1 , Lili Wang 1 , Jia Deng 3 , Bochu Wang 1 , Shilei Hao 1
Affiliation
|
Trichocyte keratins hold significant promise in accelerating wound healing. Yet it is difficult to discriminate characteristics and mechanisms from their subtypes because of the high sequence homology. Here, the distinct wound healing properties in terms of wound closure rate, epidermal regeneration and angiogenesis of 17 kinds of human hair keratins is reported. Each trichocyte keratin shows distinct behaviors with unique advantages. Amongst all, recombinant keratin (RK) 33B, RK34, RK39 and RK84 show the highest efficiency in wound closure acceleration, and RK34, RK37 and RK81 presented the strongest angiogenic performance. Furthermore, transcriptomic analysis revealed the regulatory mechanisms of trichocyte keratins in the proliferation and migration of keratinocyte and blood vessel generation. Finally, the keratins with strong re-epithelialization and angiogenic performances significantly accelerate wound closure in a diabetic rat model established in-house. The findings provide a panorama view of trichocyte keratin performance in wound healing and that may harbor potential for finely tailored keratin development and precision applications.
中文翻译：
驱动三毛细胞角蛋白在伤口愈合中独特行为的细胞机制
三毛细胞角蛋白在加速伤口愈合方面具有重要前景。然而，由于序列同源性较高，很难区分其亚型的特征和机制。在此，报道了 17 种人发角蛋白在伤口闭合率、表皮再生和血管生成方面的独特伤口愈合特性。每个毛细胞角蛋白都表现出独特的行为和独特的优势。其中，重组角蛋白（RK）33B、RK34、RK39和RK84在加速伤口闭合方面表现出最高效率，RK34、RK37和RK81表现出最强的血管生成性能。此外，转录组分析揭示了毛细胞角蛋白在角化细胞增殖和迁移以及血管生成中的调节机制。最后，具有强再上皮化和血管生成性能的角蛋白可显着加速内部建立的糖尿病大鼠模型的伤口闭合。这些发现提供了三细胞角蛋白在伤口愈合中表现的全景图，并且可能蕴藏着精细定制角蛋白发育和精确应用的潜力。
更新日期：2023-09-13
中文翻译：
驱动三毛细胞角蛋白在伤口愈合中独特行为的细胞机制
三毛细胞角蛋白在加速伤口愈合方面具有重要前景。然而，由于序列同源性较高，很难区分其亚型的特征和机制。在此，报道了 17 种人发角蛋白在伤口闭合率、表皮再生和血管生成方面的独特伤口愈合特性。每个毛细胞角蛋白都表现出独特的行为和独特的优势。其中，重组角蛋白（RK）33B、RK34、RK39和RK84在加速伤口闭合方面表现出最高效率，RK34、RK37和RK81表现出最强的血管生成性能。此外，转录组分析揭示了毛细胞角蛋白在角化细胞增殖和迁移以及血管生成中的调节机制。最后，具有强再上皮化和血管生成性能的角蛋白可显着加速内部建立的糖尿病大鼠模型的伤口闭合。这些发现提供了三细胞角蛋白在伤口愈合中表现的全景图，并且可能蕴藏着精细定制角蛋白发育和精确应用的潜力。
京公网安备 11010802027423号