基于4,6-二(2-噻吩基)噻吩并[3,4-c][1,2,5]噻二唑的双自由基有机小分子光热材料用于光热免疫治疗,Advanced Functional Materials

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基于4,6-二(2-噻吩基)噻吩并[3,4-c][1,2,5]噻二唑的双自由基有机小分子光热材料用于光热免疫治疗
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2023-09-11 , DOI: 10.1002/adfm.202306360
Chunyu Yang ₁ , Lixin Guo ₁ , Kaixin Zhang ₁ , Guan Wang ₁ , Qingsong Yu ₂ , Zhihua Gan ₂ , Xinggui Gu _{1,

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Affiliation

光热免疫疗法可以通过诱导免疫原性细胞死亡（ICD）原位产生疫苗样功能，为癌症治疗提供一种高效、便捷的策略，这高度依赖于具有优越光热效应的合适光热剂。在此，开发了一种基于4,6-二(2-噻吩基)噻吩并[3,4-c][1,2,5]噻二唑和四苯乙烯的新型双自由基有机小分子光热材料（TTD-TPE）纳米粒子表现出808 nm的近红外（NIR）吸收、约75%的高光热转换效率（PTCE）以及优异的光声成像（PAI）特性。TTD-TPE纳米颗粒优异的光热效应源于D-A相互作用、双自由基特性和激发态分子内运动的综合协同效应，不仅通过局部高温消融原发肿瘤，而且将原发肿瘤转化为疫苗通过ICD原位抑制远处和转移性肿瘤的生长，展示了光热免疫疗法的巨大潜力。因此，这一发现鼓励研究人员开发优质的有机小分子光热材料，以促进简单但有用的癌症治疗方式。

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Diradical-Featured Organic Small-Molecule Photothermal Material Based on 4,6-di(2-thienyl)thieno[3,4-c][1,2,5]thiadiazole for Photothermal Immunotherapy

Photothermal immunotherapy can provide an efficient and convenient strategy for cancer treatment by inducing immunogenic cell death (ICD) to generate vaccine-like functions in situ, which highly relies on suitable photothermal agents with superior photothermal effect. Herein, a novel diradical-featured organic small-molecule photothermal material (TTD-TPE) based on 4,6-di(2-thienyl)thieno[3,4-c][1,2,5]thiadiazole and tetraphenylethylene is developed to exhibit near-infrared (NIR) absorption of 808 nm, high photothermal conversion efficiency (PTCE) of about 75%, and superior photoacoustic imaging (PAI) property in nanoparticle. The excellent photothermal effect of TTD-TPE nanoparticles originates from the integrated synergic effect of D–A interactions, diradical character, and excited-state intramolecular motion, which not only ablates the primary tumor by localized high temperature but also transforms the primary tumor into vaccine in situ through ICD to inhibit the growth of distant and metastatic tumors, demonstrating the huge potential in photothermal immunotherapy. Thus, this finding encourage researchers to develop superior organic small-molecule photothermal materials to boost the simple but useful modality for cancer treatment.

更新日期：2023-09-11

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