A TFA-catalyzed dehydrofluorinative cyclization of 2,2-difluoro-3-hydroxy-1,4-diketones has been developed in the presence of amines under mild conditions in which the difluorinated substrates are readily prepared according to our reported literature. This protocol provides a rapid construction of fluoro 3(2H)-furanones in good to excellent yields with good functional group tolerance. Easy scale-up synthesis also shows a practical advantage.

中文翻译：

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通过 TFA 催化 2,2-二氟-3-羟基-1,4-二酮脱氟化氢环化合成氟 3(2H)-呋喃酮

根据我们报道的文献，在胺存在的温和条件下开发了 TFA 催化的 2,2-二氟-3-羟基-1,4-二酮的脱氟化氢环化，其中二氟化底物很容易制备。该方案提供了氟 3(2 H )-呋喃酮的快速构建，产率良好至优异，且具有良好的官能团耐受性。简单的放大合成也显示出实际优势。